Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis.

TitleWelcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis.
Publication TypeJournal Article
Year of Publication2015
AuthorsAlečković, M, Kang, Y
JournalCancer Cell
Volume28
Issue5
Pagination554-6
Date Published2015 Nov 9
ISSN1878-3686
KeywordsAnimals, Brain Neoplasms, Exosomes, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Male, MicroRNAs, PTEN Phosphohydrolase, Tumor Microenvironment
Abstract

<p>Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.</p>

DOI10.1016/j.ccell.2015.10.010
Alternate JournalCancer Cell
PubMed ID26555172