In vivo models of hepatitis B and C virus infection.

TitleIn vivo models of hepatitis B and C virus infection.
Publication TypeJournal Article
Year of Publication2016
AuthorsWiner, BY, Ding, Q, Gaska, JM, Ploss, A
JournalFEBS Lett
Volume590
Issue13
Pagination1987-99
Date Published2016 Jul
ISSN1873-3468
KeywordsAnimals, Disease Models, Animal, Hepatitis B, Hepatitis C, Hepatitis Viruses, Host Specificity, Humans, Species Specificity
Abstract

<p>Globally, more than 500 million individuals are chronically infected with hepatitis B (HBV), delta (HDV), and/or C (HCV) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV, HDV, and HCV, which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV, HDV, and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses.</p>

DOI10.1002/1873-3468.12157
Alternate JournalFEBS Lett.
PubMed ID27009462
PubMed Central IDPMC4945464
Grant ListR01 AI106005 / AI / NIAID NIH HHS / United States
R01 AI079031 / AI / NIAID NIH HHS / United States
R21 AI117213 / AI / NIAID NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States
R56 AI106005 / AI / NIAID NIH HHS / United States
R01 AI107301 / AI / NIAID NIH HHS / United States