Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression.

TitleVibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression.
Publication TypeJournal Article
Year of Publication2003
AuthorsMok, KC, Wingreen, NS, Bassler, BL
JournalEMBO J
Volume22
Issue4
Pagination870-81
Date Published2003 Feb 17
ISSN0261-4189
Keywords4-Butyrolactone, beta-Galactosidase, Gene Expression Regulation, Bacterial, Homoserine, Lactones, Signal Transduction, Vibrio
Abstract

<p>In a process called quorum sensing, bacteria communicate with one another by exchanging chemical signals called autoinducers. In the bioluminescent marine bacterium Vibrio harveyi, two different auto inducers (AI-1 and AI-2) regulate light emission. Detection of and response to the V.harveyi autoinducers are accomplished through two two-component sensory relay systems: AI-1 is detected by the sensor LuxN and AI-2 by LuxPQ. Here we further define the V.harveyi quorum-sensing regulon by identifying 10 new quorum-sensing-controlled target genes. Our examination of signal processing and integration in the V.harveyi quorum-sensing circuit suggests that AI-1 and AI-2 act synergistically, and that the V.harveyi quorum-sensing circuit may function exclusively as a 'coincidence detector' that discriminates between conditions in which both autoinducers are present and all other conditions.</p>

DOI10.1093/emboj/cdg085
Alternate JournalEMBO J.
PubMed ID12574123
PubMed Central IDPMC145445
Grant ListGM65859 / GM / NIGMS NIH HHS / United States