Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors.

TitleTissue morphodynamics: Translating planar polarity cues into polarized cell behaviors.
Publication TypeJournal Article
Year of Publication2016
AuthorsDevenport, D
JournalSemin Cell Dev Biol
Volume55
Pagination99-110
Date Published2016 Jul
ISSN1096-3634
Abstract

<p>The ability of cells to collectively orient and align their behaviors is essential in multicellular organisms for unidirectional cilia beating, collective cell movements, oriented cell divisions, and asymmetric cell fate specification. The planar cell polarity pathway coordinates a vast and diverse array of collective cell behaviors by intersecting with downstream pathways that regulate cytoskeletal dynamics and intercellular signaling. How the planar polarity pathway translates directional cues to produce polarized cell behaviors is the focus of this review.</p>

DOI10.1016/j.semcdb.2016.03.012
Alternate JournalSemin. Cell Dev. Biol.
PubMed ID26994528
PubMed Central IDPMC5005802
Grant ListR01 AR066070 / AR / NIAMS NIH HHS / United States