Testing odor response stereotypy in the Drosophila mushroom body.

TitleTesting odor response stereotypy in the Drosophila mushroom body.
Publication TypeJournal Article
Year of Publication2008
AuthorsMurthy, M, Fiete, I, Laurent, G
JournalNeuron
Volume59
Issue6
Pagination1009-23
Date Published2008 Sep 25
ISSN1097-4199
KeywordsAnimals, Animals, Genetically Modified, Association Learning, Behavior, Animal, Drosophila, Evoked Potentials, Genetic Markers, Mushroom Bodies, Neurons, Afferent, Neurons, Efferent, Olfactory Pathways, Patch-Clamp Techniques, Smell, Stereotyped Behavior, Synapses, Synaptic Transmission
Abstract

<p>The mushroom body is an insect brain structure required for olfactory learning. Its principal neurons, the Kenyon cells (KCs), form a large cell population. The neuronal populations from which their olfactory input derives (olfactory sensory and projection neurons) can be identified individually by genetic, anatomical, and physiological criteria. We ask whether KCs are similarly identifiable individually, using genetic markers and whole-cell patch-clamp in vivo. We find that across-animal responses are as diverse within the genetically labeled subset as across all KCs in a larger sample. These results combined with those from a simple model, using projection neuron odor responses as inputs, suggest that the precise circuit specification seen at earlier stages of odor processing is likely absent among the mushroom body KCs.</p>

DOI10.1016/j.neuron.2008.07.040
Alternate JournalNeuron
PubMed ID18817738
PubMed Central IDPMC2654402
Grant ListR01 DC007652-01A1 / DC / NIDCD NIH HHS / United States