Synchronized firing among retinal ganglion cells signals motion reversal.

TitleSynchronized firing among retinal ganglion cells signals motion reversal.
Publication TypeJournal Article
Year of Publication2007
AuthorsSchwartz, G, Taylor, S, Fisher, C, Harris, R, Berry, MJ
JournalNeuron
Volume55
Issue6
Pagination958-69
Date Published2007 Sep 20
ISSN0896-6273
KeywordsAlgorithms, Ambystoma, Animals, Electrodes, Electrophysiology, Fourier Analysis, Image Processing, Computer-Assisted, In Vitro Techniques, Mice, Mice, Inbred C57BL, Motion Perception, Photic Stimulation, Retinal Ganglion Cells, Visual Fields
Abstract

<p>We show that when a moving object suddenly reverses direction, there is a brief, synchronous burst of firing within a population of retinal ganglion cells. This burst can be driven by either the leading or trailing edge of the object. The latency is constant for movement at different speeds, objects of different size, and bright versus dark contrasts. The same ganglion cells that signal a motion reversal also respond to smooth motion. We show that the brain can build a pure reversal detector using only a linear filter that reads out synchrony from a group of ganglion cells. These results indicate that not only can the retina anticipate the location of a smoothly moving object, but that it can also signal violations in its own prediction. We show that the reversal response cannot be explained by models of the classical receptive field and suggest that nonlinear receptive field subunits may be responsible.</p>

DOI10.1016/j.neuron.2007.07.042
Alternate JournalNeuron
PubMed ID17880898
PubMed Central IDPMC3163230
Grant ListR01 EY014196 / EY / NEI NIH HHS / United States
R01 EY014196-08 / EY / NEI NIH HHS / United States
R01 EY14196 / EY / NEI NIH HHS / United States