The structure and precision of retinal spike trains.

TitleThe structure and precision of retinal spike trains.
Publication TypeJournal Article
Year of Publication1997
AuthorsBerry, MJ, Warland, DK, Meister, M
JournalProc Natl Acad Sci U S A
Volume94
Issue10
Pagination5411-6
Date Published1997 May 13
ISSN0027-8424
KeywordsAction Potentials, Ambystoma, Animals, Electrophysiology, In Vitro Techniques, Larva, Photic Stimulation, Rabbits, Reproducibility of Results, Retina, Retinal Ganglion Cells, Time Factors
Abstract

<p>Assessing the reliability of neuronal spike trains is fundamental to an understanding of the neural code. We measured the reproducibility of retinal responses to repeated visual stimuli. In both tiger salamander and rabbit, the retinal ganglion cells responded to random flicker with discrete, brief periods of firing. For any given cell, these firing events covered only a small fraction of the total stimulus time, often less than 5%. Firing events were very reproducible from trial to trial: the timing jitter of individual spikes was as low as 1 msec, and the standard deviation in spike count was often less than 0.5 spikes. Comparing the precision of spike timing to that of the spike count showed that the timing of a firing event conveyed several times more visual information than its spike count. This sparseness and precision were general characteristics of ganglion cell responses, maintained over the broad ensemble of stimulus waveforms produced by random flicker, and over a range of contrasts. Thus, the responses of retinal ganglion cells are not properly described by a firing probability that varies continuously with the stimulus. Instead, these neurons elicit discrete firing events that may be the fundamental coding symbols in retinal spike trains.</p>

Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID9144251
PubMed Central IDPMC24692