Social Evolution Selects for Redundancy in Bacterial Quorum Sensing.

TitleSocial Evolution Selects for Redundancy in Bacterial Quorum Sensing.
Publication TypeJournal Article
Year of Publication2016
AuthorsEven-Tov, E, Bendori, SOmer, Valastyan, J, Ke, X, Pollak, S, Bareia, T, Ben-Zion, I, Bassler, BL, Eldar, A
JournalPLoS Biol
Volume14
Issue2
Paginatione1002386
Date Published2016 Feb
ISSN1545-7885
KeywordsBacillus subtilis, Biological Evolution, Models, Genetic, Quorum Sensing, Selection, Genetic, Vibrio
Abstract

<p>Quorum sensing is a process of chemical communication that bacteria use to monitor cell density and coordinate cooperative behaviors. Quorum sensing relies on extracellular signal molecules and cognate receptor pairs. While a single quorum-sensing system is sufficient to probe cell density, bacteria frequently use multiple quorum-sensing systems to regulate the same cooperative behaviors. The potential benefits of these redundant network structures are not clear. Here, we combine modeling and experimental analyses of the Bacillus subtilis and Vibrio harveyi quorum-sensing networks to show that accumulation of multiple quorum-sensing systems may be driven by a facultative cheating mechanism. We demonstrate that a strain that has acquired an additional quorum-sensing system can exploit its ancestor that possesses one fewer system, but nonetheless, resume full cooperation with its kin when it is fixed in the population. We identify the molecular network design criteria required for this advantage. Our results suggest that increased complexity in bacterial social signaling circuits can evolve without providing an adaptive advantage in a clonal population.</p>

DOI10.1371/journal.pbio.1002386
Alternate JournalPLoS Biol.
PubMed ID26927849
PubMed Central IDPMC4771773
Grant List5R01 GM065859 / GM / NIGMS NIH HHS / United States
R37 GM065859 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States