Requirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat.

TitleRequirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat.
Publication TypeJournal Article
Year of Publication2015
AuthorsDuan, CA, Erlich, JC, Brody, CD
JournalNeuron
Volume86
Issue6
Pagination1491-503
Date Published2015 Jun 17
ISSN1097-4199
KeywordsAnalysis of Variance, Animals, Attention, Brain Mapping, Executive Function, Functional Laterality, GABA Agonists, Inhibition (Psychology), Learning, Male, Muscimol, Orientation, Prefrontal Cortex, Rats, Rats, Long-Evans, Reaction Time, Superior Colliculi
Abstract

<p>To study rapid sensorimotor remapping, we developed a method to train rats in a behavior in which subjects are cued, on each trial, to apply a sensorimotor association to orient either toward a visual target ("Pro") or away from it, toward its reverse ("Anti"). Multiple behavioral asymmetries suggested that Anti behavior is cognitively demanding while Pro is easier to learn and perform. This is consistent with a prominent hypothesis in the primate literature that Anti requires prefrontal cortex (PFC), whereas Pro could be mediated by midbrain superior colliculus (SC). Pharmacological inactivation of rat medial PFC supported its expected role in Anti. Remarkably, bilateral SC inactivation substantially impaired Anti while leaving Pro essentially intact. Moreover, SC inactivation eliminated the performance cost of switching from Anti to Pro tasks. Our results establish a rodent model of single-trial sensorimotor remapping and suggest a critical role for SC in the cognitively demanding Anti task.</p>

DOI10.1016/j.neuron.2015.05.042
Alternate JournalNeuron
PubMed ID26087166
Grant List / / Howard Hughes Medical Institute / United States