RAI2: Linking Retinoic Acid Signaling with Metastasis Suppression.

TitleRAI2: Linking Retinoic Acid Signaling with Metastasis Suppression.
Publication TypeJournal Article
Year of Publication2015
AuthorsEsposito, M, Kang, Y
JournalCancer Discov
Volume5
Issue5
Pagination466-8
Date Published2015 May 01
ISSN2159-8290
KeywordsBone Marrow, Breast Neoplasms, Female, Humans, Neoplastic Cells, Circulating, Proteins
Abstract

Considerable evidence points to the importance of disseminated tumor cells, which are commonly detected in the bone marrow and display features of cellular plasticity, in predicting the clinical outcome of breast cancer. In this issue of Cancer Discovery, Werner and colleagues report on the discovery of retinoic acid-induced 2 (RAI2) as a differentiation factor that suppresses early metastatic spread of estrogen receptor-positive breast cancer.

DOI10.1158/2159-8290.CD-15-0352
Alternate JournalCancer Discov
PubMed ID25941336
PubMed Central IDPMC4422076
Grant ListR01 CA141062 / CA / NCI NIH HHS / United States
R01CA141062 / CA / NCI NIH HHS / United States