Physics of Intracellular Organization in Bacteria.

TitlePhysics of Intracellular Organization in Bacteria.
Publication TypeJournal Article
Year of Publication2015
AuthorsWingreen, NS, Huang, KCasey
JournalAnnu Rev Microbiol
Volume69
Pagination361-79
Date Published2015
ISSN1545-3251
KeywordsActins, Bacteria, Bacterial Proteins, Cardiolipins
Abstract

<p>With the realization that bacteria achieve exquisite levels of spatiotemporal organization has come the challenge of discovering the underlying mechanisms. In this review, we describe three classes of such mechanisms, each of which has physical origins: the use of landmarks, the creation of higher-order structures that enable geometric sensing, and the emergence of length scales from systems of chemical reactions coupled to diffusion. We then examine the diversity of geometric cues that exist even in cells with relatively simple geometries, and end by discussing both new technologies that could drive further discovery and the implications of our current knowledge for the behavior, fitness, and evolution of bacteria. The organizational strategies described here are employed in a wide variety of systems and in species across all kingdoms of life; in many ways they provide a general blueprint for organizing the building blocks of life.</p>

DOI10.1146/annurev-micro-091014-104313
Alternate JournalAnnu. Rev. Microbiol.
PubMed ID26488278
Grant ListDP2OD006466 / OD / NIH HHS / United States