An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns.

TitleAn oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns.
Publication TypeJournal Article
Year of Publication2009
AuthorsGao, J, Schwartz, G, Berry, MJ, Holmes, P
JournalNetwork
Volume20
Issue2
Pagination106-35
Date Published2009
ISSN1361-6536
KeywordsAnimals, Models, Neurological, Photic Stimulation, Retinal Bipolar Cells, Retinal Ganglion Cells
Abstract

<p>Neurons in diverse brain areas can respond to the interruption of a regular stimulus pattern by firing bursts of spikes. Here we describe a simple model, which permits such responses to periodic stimuli over a substantial frequency range. Focusing on the omitted stimulus response (OSR) in isolated retinas subjected to periodic patterns of dark flashes, we develop a biophysically-realistic model which accounts for resonances in ON bipolar cells. The bipolar cell terminal contains an LRC oscillator whose inductance is modulated by a transient calcium concentration, thus adjusting its resonant frequency to approximately match that of the stimulus. The model reproduces ganglion cell outputs, which sum the ON and OFF bipolar pathways, and it responds to omitted flashes with approximately constant latencies, as observed experimentally.</p>

DOI10.1080/09548980902991705
Alternate JournalNetwork
PubMed ID19568983
PubMed Central IDPMC2752637
Grant ListP50 MH062196-09 / MH / NIMH NIH HHS / United States