A new cap for kinetochore fibre minus ends.

TitleA new cap for kinetochore fibre minus ends.
Publication TypeJournal Article
Year of Publication2011
AuthorsPetry, S, Vale, RD
JournalNat Cell Biol
Volume13
Issue12
Pagination1389-91
Date Published2011 Nov 13
ISSN1476-4679
KeywordsAnimals, Chromosome Segregation, Humans, Kinetochores, Nuclear Proteins, ran GTP-Binding Protein, RNA-Binding Proteins, Spindle Apparatus
Abstract

<p>In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.</p>

DOI10.1038/ncb2387
Alternate JournalNat. Cell Biol.
PubMed ID22081093
PubMed Central IDPMC3532025
Grant ListK99 GM100013 / GM / NIGMS NIH HHS / United States
R01 GM038499 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States