Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.

TitleLnc-ing ROR1-HER3 and Hippo signalling in metastasis.
Publication TypeJournal Article
Year of Publication2017
AuthorsZhuo, W, Kang, Y
JournalNat Cell Biol
Volume19
Issue2
Pagination81-83
Date Published2017 01 31
ISSN1476-4679
Abstract

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

DOI10.1038/ncb3467
Alternate JournalNat. Cell Biol.
PubMed ID28139652