Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.

TitleLeft-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.
Publication TypeJournal Article
Year of Publication2017
AuthorsGrimes, DT, Burdine, RD
JournalTrends Genet
Date Published2017 Jul 15
ISSN0168-9525
Abstract

Vertebrates exhibit striking left-right (L-R) asymmetries in the structure and position of the internal organs. Symmetry is broken by motile cilia-generated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robustly established within mesodermal tissue on the left side only. This pathway impinges upon various organ primordia to instruct their side-specific development. Recently, progress has been made in understanding both the breaking of embryonic L-R symmetry and how the Nodal-Pitx2 pathway controls lateralized cell differentiation, migration, and other aspects of cell behavior, as well as tissue-level mechanisms, that drive asymmetries in organ formation. Proper execution of asymmetric organogenesis is critical to health, making furthering our understanding of L-R development an important concern.

DOI10.1016/j.tig.2017.06.004
Alternate JournalTrends Genet.
PubMed ID28720483
Grant ListR01 HD048584 / HD / NICHD NIH HHS / United States