Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses.

TitleIntrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses.
Publication TypeJournal Article
Year of Publication2017
AuthorsEnquist, LW, Leib, DA
JournalJ Virol
Volume91
Issue1
Date Published2017 01 01
ISSN1098-5514
Abstract

Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.

DOI10.1128/JVI.01200-16
Alternate JournalJ. Virol.
PubMed ID27795407
PubMed Central IDPMC5165195
Grant ListR01 NS033506 / NS / NINDS NIH HHS / United States
R01 EY009083 / EY / NEI NIH HHS / United States
P01 AI098681 / AI / NIAID NIH HHS / United States
R01 NS060699 / NS / NINDS NIH HHS / United States
R37 NS033506 / NS / NINDS NIH HHS / United States