Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens.

TitleIntricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens.
Publication TypeJournal Article
Year of Publication2015
AuthorsBudayeva, HG, Rowland, EA, Cristea, IM
JournalJ Virol
Volume90
Issue1
Pagination5-8
Date Published2015 10 21
ISSN1098-5514
KeywordsAnimals, Host-Pathogen Interactions, Humans, Metabolic Networks and Pathways, Models, Biological, Sirtuins, Virus Diseases
Abstract

For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.

DOI10.1128/JVI.03220-14
Alternate JournalJ. Virol.
PubMed ID26491165
PubMed Central IDPMC4702534
Grant ListR01 GM114141 / GM / NIGMS NIH HHS / United States
AI102187 / AI / NIAID NIH HHS / United States
GM114141 / GM / NIGMS NIH HHS / United States
HL127640 / HL / NHLBI NIH HHS / United States