HUMAN MICROBIOTA. Small molecules from the human microbiota.

TitleHUMAN MICROBIOTA. Small molecules from the human microbiota.
Publication TypeJournal Article
Year of Publication2015
AuthorsDonia, MS, Fischbach, MA
JournalScience
Volume349
Issue6246
Pagination1254766
Date Published2015 Jul 24
ISSN1095-9203
KeywordsAntibiosis, Bacteriocins, Biological Products, Enterotoxins, Glycolipids, Humans, Immunomodulation, Microbiota, Oligosaccharides, Peptides, Protein Processing, Post-Translational, Ribosomes, Terpenes
Abstract

<p>Developments in the use of genomics to guide natural product discovery and a recent emphasis on understanding the molecular mechanisms of microbiota-host interactions have converged on the discovery of small molecules from the human microbiome. Here, we review what is known about small molecules produced by the human microbiota. Numerous molecules representing each of the major metabolite classes have been found that have a variety of biological activities, including immune modulation and antibiosis. We discuss technologies that will affect how microbiota-derived molecules are discovered in the future and consider the challenges inherent in finding specific molecules that are critical for driving microbe-host and microbe-microbe interactions and understanding their biological relevance.</p>

DOI10.1126/science.1254766
Alternate JournalScience
PubMed ID26206939
PubMed Central IDPMC4641445
Grant ListR01 AI101018 / AI / NIAID NIH HHS / United States
DP2 OD007290 / OD / NIH HHS / United States
R01 DK101674 / DK / NIDDK NIH HHS / United States
GM081879 / GM / NIGMS NIH HHS / United States
AI101018 / AI / NIAID NIH HHS / United States
DK101674 / DK / NIDDK NIH HHS / United States
P50 GM081879 / GM / NIGMS NIH HHS / United States
OD007290 / OD / NIH HHS / United States