Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.

TitleHighly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.
Publication TypeJournal Article
Year of Publication2014
AuthorsPerez, LJ, Karagounis, TK, Hurley, A, Bassler, BL, Semmelhack, MF
JournalChem Sci
Volume5
Issue1
Pagination151-155
Date Published2014 Jan 1
ISSN2041-6520
Abstract

<p>In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.</p>

DOI10.1039/C3SC52572D
Alternate JournalChem Sci
PubMed ID24436778
PubMed Central IDPMC3890260
Grant ListR01 GM065859 / GM / NIGMS NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States