High-fidelity coding with correlated neurons.

TitleHigh-fidelity coding with correlated neurons.
Publication TypeJournal Article
Year of Publication2014
Authorsda Silveira, RAzeredo, Berry, MJ
JournalPLoS Comput Biol
Volume10
Issue11
Paginatione1003970
Date Published2014 Nov
ISSN1553-7358
KeywordsAction Potentials, Computational Biology, Models, Neurological, Neurons
Abstract

<p>Positive correlations in the activity of neurons are widely observed in the brain. Previous studies have shown these correlations to be detrimental to the fidelity of population codes, or at best marginally favorable compared to independent codes. Here, we show that positive correlations can enhance coding performance by astronomical factors. Specifically, the probability of discrimination error can be suppressed by many orders of magnitude. Likewise, the number of stimuli encoded--the capacity--can be enhanced more than tenfold. These effects do not necessitate unrealistic correlation values, and can occur for populations with a few tens of neurons. We further show that both effects benefit from heterogeneity commonly seen in population activity. Error suppression and capacity enhancement rest upon a pattern of correlation. Tuning of one or several effective parameters can yield a limit of perfect coding: the corresponding pattern of positive correlation leads to a 'lock-in' of response probabilities that eliminates variability in the subspace relevant for stimulus discrimination. We discuss the nature of this pattern and we suggest experimental tests to identify it.</p>

DOI10.1371/journal.pcbi.1003970
Alternate JournalPLoS Comput. Biol.
PubMed ID25412463
PubMed Central IDPMC4238954
Grant ListEY014196 / EY / NEI NIH HHS / United States