Exploring and Exploiting Proteome Organization during Viral Infection.

TitleExploring and Exploiting Proteome Organization during Viral Infection.
Publication TypeJournal Article
Year of Publication2017
AuthorsBeltran, PMJean, Cook, KC, Cristea, IM
JournalJ Virol
Date Published2017 Jul 05
ISSN1098-5514
Abstract

Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have and will continue to help define mechanisms used by viruses to exploit host proteome organization.

DOI10.1128/JVI.00268-17
Alternate JournalJ. Virol.
PubMed ID28679763