Establishing and maintaining cell polarity with mRNA localization in Drosophila.

TitleEstablishing and maintaining cell polarity with mRNA localization in Drosophila.
Publication TypeJournal Article
Year of Publication2016
AuthorsBarr, J, Yakovlev, KV, Shidlovskii, ii, Y, Schedl, P
JournalBioessays
Volume38
Issue3
Pagination244-53
Date Published2016 Mar
ISSN1521-1878
Abstract

<p>How cell polarity is established and maintained is an important question in diverse biological contexts. Molecular mechanisms used to localize polarity proteins to distinct domains are likely context-dependent and provide a feedback loop in order to maintain polarity. One such mechanism is the localized translation of mRNAs encoding polarity proteins, which will be the focus of this review and may play a more important role in the establishment and maintenance of polarity than is currently known. Localized translation of mRNAs encoding polarity proteins can be used to establish polarity in response to an external signal, and to maintain polarity by local production of polarity determinants. The importance of this mechanism is illustrated by recent findings, including orb2-dependent localized translation of aPKC mRNA at the apical end of elongating spermatid tails in the Drosophila testis, and the apical localization of stardust A mRNA in Drosophila follicle and embryonic epithelia.</p>

DOI10.1002/bies.201500088
Alternate JournalBioessays
PubMed ID26773560
PubMed Central IDPMC4871591
Grant ListR01 GM110015 / GM / NIGMS NIH HHS / United States
GMRO1110015 / / PHS HHS / United States