Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.

TitleEpithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.
Publication TypeJournal Article
Year of Publication2017
AuthorsOsterfield, M, Berg, CA, Shvartsman, SY
JournalDev Cell
Volume41
Issue4
Pagination337-348
Date Published2017 May 22
ISSN1878-1551
Abstract

Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify unique cell types that construct epithelial tubes for specialized eggshell structures, has provided a tractable system to ask these questions. Work there has elucidated connections between scales of development, including across evolutionary scales, and fostered the development of quantitative modeling tools. These tools and general principles can be applied to the understanding of other developmental processes across organisms.

DOI10.1016/j.devcel.2017.02.018
Alternate JournalDev. Cell
PubMed ID28535370
PubMed Central IDPMC5443119
Grant ListR01 GM079433 / GM / NIGMS NIH HHS / United States
R01 GM107103 / GM / NIGMS NIH HHS / United States