Efficiency of information transmission by retinal ganglion cells.

TitleEfficiency of information transmission by retinal ganglion cells.
Publication TypeJournal Article
Year of Publication2004
AuthorsKoch, K, McLean, J, Berry, M, Sterling, P, Balasubramanian, V, Freed, MA
JournalCurr Biol
Volume14
Issue17
Pagination1523-30
Date Published2004 Sep 7
ISSN0960-9822
KeywordsAction Potentials, Animals, Electrophysiology, Guinea Pigs, Models, Neurological, Photic Stimulation, Retinal Ganglion Cells, Signal Transduction, Synaptic Transmission, Time Factors, Visual Perception
Abstract

<p><b>BACKGROUND: </b>Different types of retinal ganglion cells convey different messages to the brain. Messages are in the form of spike patterns, and the number of possible patterns per second sets the coding capacity. We asked if different ganglion cell types make equally efficient use of their coding capacity or whether efficiency depends on the message conveyed.</p><p><b>RESULTS: </b>We recorded spike trains from retinal ganglion cells in an in vitro preparation of the guinea pig retina. By calculating, for the observed spike rate, the number of possible spike patterns per second, we calculated coding capacity, and by counting the actual number of patterns, we estimated information rate. Cells with "brisk" responses, i.e., high firing rates, and a general message transmitted information at high rates (21 +/- 9 bits s(-1)). Cells with "sluggish" responses, i.e., lower firing rates, and specific messages (direction of motion, local-edge) transmitted information at lower rates (13 +/- 7 bits s(-1)). Yet, for every type of ganglion cell examined, the information rate was about one-third of coding capacity. For every ganglion cell, information rate was very close (within 4%) to that predicted from Poisson noise and the cell's actual time-modulated rate.</p><p><b>CONCLUSIONS: </b>Different messages are transmitted with similar efficiency. Efficiency is limited by temporal correlations, but correlations may be essential to improve decoding in the presence of irreducible noise.</p>

DOI10.1016/j.cub.2004.08.060
Alternate JournalCurr. Biol.
PubMed ID15341738
Grant ListEY 014196-02 / EY / NEI NIH HHS / United States
EY00828 / EY / NEI NIH HHS / United States
T32 EY07035 / EY / NEI NIH HHS / United States