The diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane.

TitleThe diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane.
Publication TypeJournal Article
Year of Publication2016
AuthorsBosse, JB, Enquist, LW
JournalNucleus
Volume7
Issue1
Pagination13-9
Date Published2016
ISSN1949-1042
Abstract

<p>Herpesviruses are large DNA viruses that utilize the host nucleus for genome replication as well as capsid assembly. After maturation, these 125 nm large capsid assemblies must cross the nucleoplasm to engage the nuclear envelope and bud into the cytoplasm. Here we summarize our recent findings how this motility is facilitated. We suggest that herpesvirus induced nuclear remodeling allows capsids to move by diffusion in the nucleus and not by motor-dependent transport.</p>

DOI10.1080/19491034.2016.1149665
Alternate JournalNucleus
PubMed ID26889771
PubMed Central IDPMC4916875
Grant ListNS033506 / NS / NINDS NIH HHS / United States
NS060699 / NS / NINDS NIH HHS / United States
R01 NS033506 / NS / NINDS NIH HHS / United States
R01 NS060699 / NS / NINDS NIH HHS / United States