Cutting through the complexity of cell collectives.

TitleCutting through the complexity of cell collectives.
Publication TypeJournal Article
Year of Publication2013
AuthorsNadell, CD, Bucci, V, Drescher, K, Levin, SA, Bassler, BL, Xavier, JB
JournalProc Biol Sci
Volume280
Issue1755
Pagination20122770
Date Published2013 Mar 22
ISSN1471-2954
KeywordsBacteria, Bacterial Physiological Phenomena, Biofilms, Biological Evolution, Models, Biological, Quorum Sensing, Selection, Genetic
Abstract

<p>Via strength in numbers, groups of cells can influence their environments in ways that individual cells cannot. Large-scale structural patterns and collective functions underpinning virulence, tumour growth and bacterial biofilm formation are emergent properties of coupled physical and biological processes within cell groups. Owing to the abundance of factors influencing cell group behaviour, deriving general principles about them is a daunting challenge. We argue that combining mechanistic theory with theoretical ecology and evolution provides a key strategy for clarifying how cell groups form, how they change in composition over time, and how they interact with their environments. Here, we review concepts that are critical for dissecting the complexity of cell collectives, including dimensionless parameter groups, individual-based modelling and evolutionary theory. We then use this hybrid modelling approach to provide an example analysis of the evolution of cooperative enzyme secretion in bacterial biofilms.</p>

DOI10.1098/rspb.2012.2770
Alternate JournalProc. Biol. Sci.
PubMed ID23363630
PubMed Central IDPMC3574390
Grant List1-U54-CA148967-01 / CA / NCI NIH HHS / United States
5R01GM065859 / GM / NIGMS NIH HHS / United States
DP2 OD008440 / OD / NIH HHS / United States
DP2OD008440 / OD / NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
R01 GM065859 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States