Connecting Neural Codes with Behavior in the Auditory System of Drosophila.

TitleConnecting Neural Codes with Behavior in the Auditory System of Drosophila.
Publication TypeJournal Article
Year of Publication2015
AuthorsClemens, J, Girardin, CC, Coen, P, Guan, X-J, Dickson, BJ, Murthy, M
JournalNeuron
Volume87
Issue6
Pagination1332-43
Date Published2015 Sep 23
ISSN1097-4199
KeywordsAcoustic Stimulation, Animals, Animals, Genetically Modified, Auditory Pathways, Auditory Perception, Drosophila, Female, Male, Sexual Behavior, Animal, Vocalization, Animal
Abstract

<p>Brains are optimized for processing ethologically relevant sensory signals. However, few studies have characterized the neural coding mechanisms that underlie the transformation from natural sensory information to behavior. Here, we focus on acoustic communication in Drosophila melanogaster and use computational modeling to link natural courtship song, neuronal codes, and female behavioral responses to song. We show that melanogaster females are sensitive to long timescale song structure (on the order of tens of seconds). From intracellular recordings, we generate models that recapitulate neural responses to acoustic stimuli. We link these neural codes with female behavior by generating model neural responses to natural courtship song. Using a simple decoder, we predict female behavioral responses to the same song stimuli with high accuracy. Our modeling approach reveals how long timescale song features are represented by the Drosophila brain and how neural representations can be decoded to generate behavioral selectivity for acoustic communication signals.</p>

DOI10.1016/j.neuron.2015.08.014
Alternate JournalNeuron
PubMed ID26365767
PubMed Central IDPMC4629847
Grant ListDP2 NS092378 / NS / NINDS NIH HHS / United States