The cell biology of planar cell polarity.

TitleThe cell biology of planar cell polarity.
Publication TypeJournal Article
Year of Publication2014
AuthorsDevenport, D
JournalJ Cell Biol
Volume207
Issue2
Pagination171-9
Date Published2014 Oct 27
ISSN1540-8140
KeywordsAnimals, Body Patterning, Cell Communication, Cell Polarity, Cues, Drosophila, Models, Biological, Signal Transduction
Abstract

<p>Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells. Recent progress has been made toward understanding how protein transport, endocytosis, and intercellular interactions contribute to asymmetric PCP protein localization. Additionally, the functions of gradients and mechanical forces as global cues that bias PCP orientation are beginning to be elucidated. Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level.</p>

DOI10.1083/jcb.201408039
Alternate JournalJ. Cell Biol.
PubMed ID25349257
PubMed Central IDPMC4210441