Building the Microtubule Cytoskeleton Piece by Piece.

TitleBuilding the Microtubule Cytoskeleton Piece by Piece.
Publication TypeJournal Article
Year of Publication2015
AuthorsAlfaro-Aco, R, Petry, S
JournalJ Biol Chem
Volume290
Issue28
Pagination17154-62
Date Published2015 Jul 10
ISSN1083-351X
KeywordsAnimals, Cytoskeleton, Female, Humans, Microtubule-Associated Proteins, Microtubules, Models, Biological, Molecular Motor Proteins, Spindle Apparatus, Xenopus laevis
Abstract

<p>The microtubule (MT) cytoskeleton gives cells their shape, organizes the cellular interior, and segregates chromosomes. These functions rely on the precise arrangement of MTs, which is achieved by the coordinated action of MT-associated proteins (MAPs). We highlight the first and most important examples of how different MAP activities are combined in vitro to create an ensemble function that exceeds the simple addition of their individual activities, and how the Xenopus laevis egg extract system has been utilized as a powerful intermediate between cellular and purified systems to uncover the design principles of self-organized MT networks in the cell.</p>

DOI10.1074/jbc.R115.638452
Alternate JournalJ. Biol. Chem.
PubMed ID25957410
PubMed Central IDPMC4498055
Grant List4R00GM100013 / GM / NIGMS NIH HHS / United States
R00 GM100013 / GM / NIGMS NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States