Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes.

TitleBoundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes.
Publication TypeJournal Article
Year of Publication2017
AuthorsChetverina, D, Fujioka, M, Erokhin, M, Georgiev, P, Jaynes, JB, Schedl, P
JournalBioessays
Date Published2017 Jan 30
ISSN1521-1878
Abstract

Chromosomes in multicellular animals are subdivided into a series of looped domains. In addition to being the underlying principle for organizing the chromatin fiber, looping is critical for processes ranging from gene regulation to recombination and repair. The subdivision of chromosomes into looped domains depends upon a special class of architectural elements called boundaries or insulators. These elements are distributed throughout the genome and are ubiquitous building blocks of chromosomes. In this review, we focus on features of boundaries that are critical in determining the topology of the looped domains and their genetic properties. We highlight the properties of fly boundaries that are likely to have an important bearing on the organization of looped domains in vertebrates, and discuss the functional consequences of the observed similarities and differences.

DOI10.1002/bies.201600233
Alternate JournalBioessays
PubMed ID28133765
Grant ListR01 GM043432 / GM / NIGMS NIH HHS / United States