Bone metastasis and the metastatic niche.

TitleBone metastasis and the metastatic niche.
Publication TypeJournal Article
Year of Publication2015
AuthorsRen, G, Esposito, M, Kang, Y
JournalJ Mol Med (Berl)
Volume93
Issue11
Pagination1203-12
Date Published2015 Nov 01
ISSN1432-1440
KeywordsAnimals, Bone Neoplasms, Humans, Neoplasm Metastasis, Neoplasms, Tumor Microenvironment
Abstract

The bone marrow has been long known to host a unique environment amenable to colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within this specialized microenvironment which give rise to the high incidence of bone metastasis in breast and prostate cancer patients have long remained uncharacterized. With the recent description of the bone metastatic "niche," considerable focus has been placed on understanding how the bone stroma contributes to each step of metastasis. Discoveries within this field have demonstrated that when cancer cells home to the niche in which hematopoietic and mesenchymal stem/progenitor cells normally reside, a bidirectional crosstalk emerges between the tumor cells and the bone metastatic stroma. This communication modulates every step of cancer cell metastasis to the bone, including the initial homing and seeding, formation of micrometastases, outgrowth of macrometastases, and the maintenance of long-term dormancy of disseminated tumor cells in the bone. In clinical practice, targeting the bone metastatic niche is evolving into a promising avenue for the prevention of bone metastatic relapse, therapeutic resistance, and other aspects of cancer progression. Here, we review the current knowledge concerning the role of the bone metastatic niche in bone metastasis.

DOI10.1007/s00109-015-1329-4
Alternate JournalJ. Mol. Med.
PubMed ID26275789
PubMed Central IDPMC4636917
Grant ListR01CA134519 / CA / NCI NIH HHS / United States
K99CA188093 / CA / NCI NIH HHS / United States
R01 CA141062 / CA / NCI NIH HHS / United States
K99 CA188093 / CA / NCI NIH HHS / United States
R01 CA134519 / CA / NCI NIH HHS / United States
R01CA141062 / CA / NCI NIH HHS / United States