Bacterial quorum sensing: its role in virulence and possibilities for its control.

TitleBacterial quorum sensing: its role in virulence and possibilities for its control.
Publication TypeJournal Article
Year of Publication2012
AuthorsRutherford, ST, Bassler, BL
JournalCold Spring Harb Perspect Med
Volume2
Issue11
Date Published2012 Nov 01
ISSN2157-1422
KeywordsBacillus cereus, Bacterial Infections, Gene Expression Regulation, Humans, Pseudomonas aeruginosa, Quorum Sensing, Staphylococcus aureus, Vibrio cholerae, Virulence Factors
Abstract

<p>Quorum sensing is a process of cell-cell communication that allows bacteria to share information about cell density and adjust gene expression accordingly. This process enables bacteria to express energetically expensive processes as a collective only when the impact of those processes on the environment or on a host will be maximized. Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria. Here we review the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae. We outline these canonical quorum-sensing mechanisms and how each uniquely controls virulence factor production. Additionally, we examine recent efforts to inhibit quorum sensing in these pathogens with the goal of designing novel antimicrobial therapeutics.</p>

DOI10.1101/cshperspect.a012427
Alternate JournalCold Spring Harb Perspect Med
PubMed ID23125205
PubMed Central IDPMC3543102
Grant List5R01AI054442 / AI / NIAID NIH HHS / United States
5R01GM065859 / GM / NIGMS NIH HHS / United States
F32 AI085922 / AI / NIAID NIH HHS / United States
F32AI085922 / AI / NIAID NIH HHS / United States
R01 GM065859 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States