Charles Miller Awarded the F30 NIH/NRSA Fellowship
Charles Miller, MD/PhD student in the Schwarzbauer lab, was awarded the F30 NIH/NRSA fellowship for his research proposal Mesangial cell matrix deposition in high glucose as a model of diabetic glomerulosclerosis.
Chronically high blood sugar levels in diabetes mellitus can have devastating effects on the kidney's filtration apparatus. This apparatus depends on proper organization of a network of proteins called the extracellular matrix, which accumulate in excess and block filtration when exposed to high sugar levels. Using a kidney cell culture model, we plan to clarify the effects of high sugar levels on the filtration matrix in hopes of revealing new targets for future therapies aimed at reversing the progression of this increasingly common and potentially deadly disease.