Faculty Research in the News

Princeton Breakthrough in Cholera Research

A team of Princeton scientists has discovered a key mechanism in how bacteria communicate with each other, a pivotal breakthrough that could lead to treatments for cholera and other bacterial diseases.

The mechanism is a chemical that cholera bacteria use for transmitting messages to each other, known as CAI-1, and has been isolated in the lab of molecular biologist Bonnie Bassler. Her team has shown that the chemical also can be used to disrupt the communication that exists among the bacteria, potentially halting the disease's progress. The discovery could lead to an entirely new class of antibiotics.

"Disease-causing bacteria talk to each other with a chemical vocabulary, and now we can interfere with their talk to control infections," said Doug Higgins, a graduate student in Bassler's lab and first author of the research team's paper on the findings. "This paper specifically concerns cholera, but it provides proof in principle that we can do it with any bacteria." Read more:

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