Lab News

Ploss Research Cited in Cell Research

Ploss research cited in Binder M, Bartenschlager R. (2013) Hepatitis C: A mouse at the end of the tunnel. Cell Res. in press

Link to online article

Ploss Research Cited in the Journal of Hepatology

Ploss research cited in Mailly L, Zeisel MB, Baumert TF. (2013) Genetically humanized mice recapitulate the entire hepatitis C virus life cycle. J Hepatology. in press

link to online article

New mouse model for hepatitis C (Nature)

Hepatitis C affects about three million people in the U.S. and is a leading cause of chronic liver disease, so creating a vaccine and new treatments is an important public health goal. Most research to date has been done in chimpanzees because they are one of a handful of species that become infected and spread the virus.

Quest to find new mouse modules for liver diseases

Knowledge of the development and progression of liver diseases as well as the generation of efficient and effective therapeutics has been hampered by the lack of animal models of liver disease. Now, two papers published in Nature and the American Journal of Physiology—Gastrointestinal and Liver Physiology have used mouse models to advance the quest to understand and treat hepatitis C and NASH.

A blue-print towards a mouse animal model for HCV infection

Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines.