Molecular architecture and function of the microtubule cytoskeleton

Petry Lab Media

Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2

Microtubules (red with growing tips in green) grow off the wall of existing microtubules, which is visualized by total internal reflection (TIRF) microscopy. This recently uncovered mechanism, termed branching microtubule nucleation, amplifies microtubules while preserving their polarity and is needed to assemble the mitotic spindle of a dividing cell (Petry et al., Cell 2013).