Welcome to the Korennykh Lab
We aim to understand mechanisms of human innate immunity, response to damage, and stress. In particular, we are interested in structural and cell biology of pathways mediated by dsRNA, other kinds of RNA, and by receptor proteins that recognize or process these RNA molecules.
Intracellular response to dsRNA
Double-stranded RNA or dsRNA is a major regulator of gene expression in all mammalian cells. A number of membrane-tethered, cytosolic and nuclear proteins serve as receptors that recognize dsRNA and control dsRNA response. Often, dsRNA response is linked to the production of interferons, pro-inflammatory cytokines and control of innate and adaptive immunity.
Broader roles of these programs in homeostasis, cell cycle, differentiation, senescence and aging are also emerging.
Read more: Korennykh Lab Research