Kang Lab Publications

2013

Ell B, Mercatali L, Ibrahim T, Campbell N, Schwarzenbach H, Pantel K, Amadori D, and Kang Y. (2013) Tumor-induced miRNA changes in osteoclast as mediators and biomarkers of osteolytic bone metastasis. Cancer Cell. in press.

Deng Y, Huang Z, Xu Y, Jin J, Zhuo W, Zhang C, Zhang X, Shen M, Yan X, Wang L, Wang X, Kang Y, Si J, and Zhou T (2013) MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett. [Epub ahead of print].

Smith HA, Kang Y., (2013) Acute Infection Induces a Metastatic Niche: A Double Menace for Cancer Patients., Clin Cancer Res. [Epub ahead of print]

Wan L, Kang Y. (2013) Pleiotropic Roles of AEG-1/MTDH/LYRIC in Breast Cancer.Adv Cancer Res. 120: 113-34.

Alexia C, Carvalho G, Poalas K, Zemirli N, Carvalho G, Zemirli N, Dwyer J, Dubois S, Hatchi E, Cordeiro N, Smith SS, Castanier C, Le Guelte A, Wan L, Kang Y, Vazquez A, Gavard J, Arnoult D, and Bidère N (2013) The endoplasmic reticulum acts as a platform for ubiquitylated components of nuclear factor κB signaling. Science Signaling, 291:1-8.

Ell B, Kang Y. (2013) Transcriptional control of cancer metastasis.Trends Cell Biol.  [Epub ahead of print]

Leroy G, DiMaggio PA, Chan EY, Zee BM, Blanco MA, Bryant B, Flaniken IZ, Liu S, Kang Y, Trojer P, and Garcia BA. (2013) A Quantitative Atlas of Histone Modification Signatures from Human Cancer Cells.Epigenetics & Chromatin, 6(1):20.

Goode G, Ballard BR, Manning HC, Freeman M, Kang Y and Eltom SE (2013) Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int. J. Cancer, [Epub ahead of print].

Lee J-Y, Park MK, Park J-H, Lee HJ, Shin DH, Kang Y, Lee CH and Kong G (2013) Loss of the polycomb group protein Mel-18 enhances the epithelial–mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. Oncogene, Mar 11. doi: 10.1038/onc.2013.53. [Epub ahead of print].

Kang Y. (2013) Imaging TGFβ signaling in mouse models of cancer metastasis. Methods Mol. Biol., in press.

Lee ST, Feng M, Wei Y, Wong CH, Qiao Y, Guan P, Li Z, Aau M, Jiang X, Karuturi KM, Tan EY, Hoon D, Kang Y and Yu Q (2013) Functional genomic analysis identifies tyrosine protein phosphatase UBASH3B as a crucial node of gene network driving tumor invasion and metastasis. Proc. Natl. Acad. Sci., 110(27):11121-6.

Kang Y, Pantel K. (2013) Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell. 23: 573-81. 

Zheng H, Kang Y. (2013) Multilayer control of the EMT master regulators.Oncogene. [Epub ahead of print]

Smith HA, Kang Y. (2013) The metastasis-promoting roles of tumor-associated immune cells.J Mol Med (Berl). 91: 411-29.

Hitosugi T, Zhou L, Elf S, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu T-L, Alečković M, LeRoy G, Kang Y, Kang H, Seo J, Shan C, Jin P, Gong W, Lonial S, Arellano ML, Khoury HJ, Chen GZ, Shin DM, Khuri FR, Boggon TJ, Kang S, He C, and Chen J (2013) Y26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nature Communications, 4:1790.

Ren G, Kang Y. (2013) A one-two punch of miR-126/126* against metastasis.Nat Cell Biol. 15: 231-3. 

Wendt MK, Schiemann BJ, Parvani JG, Lee Y-H, Kang Y, and Schiemann WP. (2013) TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer. Oncogene, 32(16):2005-15.

Fang W, Wei Y, Kang Y, Landweber LF. (2012) Detection of a common chimeric transcript between human chromosomes 7 and 16.Biol Direct. 7: 49. 

DeGraff D, Robinson VL, Shah JB, Brandt W, Sonpavde G, Kang Y, Liebert M, Wu X-R and Taylor JA (2012) Current pre-clinical models for the advancement of translational bladder cancer research. Mol. Cancer Ther., 12:121-30.

2012

Ell B, Kang Y. (2012) SnapShot: bone metastasis. Cell. 151: 690-690.

Hitosugi T, Zhou L, Elf S, Fan J, Kang H, Seo J, Shan C, Dai Q, Zhang L, Xie J, Gu T, Jin P, Alečković M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan C-H, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BJ, Ye K, Boggon TJ, Kang S, He C, and Chen J (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell, 22:585-600. (Featured Article)
Editorial by: Chaneton B and Gottlieb E. (2012) Cancer Cell, 22:565-566.

Chakrabarti R, Hwang J, Andres Blanco M [...] Kang Y. (2012) Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol. 14: 1212-22. 

Liang Y, Chong R, Lei R, Wu H, Wei Y, Lu X, Tagkopoulos L, Kung S, Yang Q, Hu G, and Kang Y (2012) Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer metastasis to bone. J. Biol. Chem., 287(40):33533-44.

Chakrabarti R, Wei Y, Romano RA, DeCoste C, Kang Y, Sinha S. (2012) Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling.Stem Cells. 30: 1496-508. 

Celià-Terrassa T, Meca-Cortés Ó, Mateo F, Martínez de Paz1 A, Rubio N, Arnal-Estapé A, Ell, BJ, Bermudo R, Díaz A, Guerra-Rebollo, Lozano JJ, Estarás C, Milà J, Vilella R, Paciucci R, García de Herreros A, Gomis RR, Kang Y, Blanco J, Fernández PL, and Thomson TM. (2012) Epithelial-mesenchymal transition can suppress major attributes of epithelial tumour-initiating cells. J. Clin. Invest., 122(5):1849-68.

Peinado H, Alečković M, Lavotshkin S, Costa da Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar CM, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. (2012) Melanoma-derived exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype. Nature Medicine, 18(6):883-91.
Editorial by: Alderton GK. (2012) Nat Rev Cancer, 12 (7): 447.
Somasundaram R and Herlyn M. (2012) Nat Medicine, 18 (6): 853-4.
McKenna ES. (2012) Cancer Discovery, 2 (7): 578.

Blanco MA, Leroy G, Khan Z, Alečković M, Zee BM, Garcia BA, Kang Y. (2012) Global secretome analysis identifies novel mediators of bone metastasis.Cell Res. 22: 1339-1355. 

Koh BI, Kang Y. (2012) The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells.EMBO Rep. 13: 412-422.

Sethi N and Kang Y. (2011) Notch signaling in cancer progression and bone metastasis.Br. J. Cancer, 105:735-48.

Sethi N and Kang Y. (2011) Notch signaling: mediator and therapeutic target of bone metastasis. IBMS BoneKEy, 8(10)

2011

Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, Yan J, Hua Y, Tiede BJ, Lu X, Haffty BG, Pantel K, Massagué J, Kang Y. (2011) VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell. 20: 701-714.

Sethi N and Kang Y. (2011) Unraveling the complexity of metastasis: molecular understanding and targeted therapeutics. Nature Reviews Cancer, 11(10):735-748. (Part of the "The next 10 years" special series)

Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celià-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y, Wei Y, Hu G, Garcia BA, Ragoussis J, Amadori D, Harris AL, Kang Y. (2011) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 17: 1101-1108. 

Ibrahim T, Sacanna E, Gaudio M, Mercatali L, Scarpi E, Zoli W, Serra P, Ricci R, Serra L, Kang Y, Amadori D. (2011) Role of RANK, RANKL, OPG, and CXCR4 Tissue Markers in Predicting Bone Metastases in Breast Cancer Patients. Clin. Breast Cancer. 11(6):369-75.

X, Kang Y. (2011) Cell fusion hypothesis of the cancer stem cell. Adv Exp Med Biol. 714: 129-140.

Mercatali L, Ibrahim T, Sacanna E, Flamini E, Scarpi E, Calistri D, Ricci M, Serra P, Ricci R, Zoli W, Kang Y, and Amadori D. (2011) Bone metastases detection by circulating biomarkers: OPG and RANK-L. Int. J. Oncol., 9(1):30.

Blanco MA, Aleckovic M, Hua Y, Li T, Wei Y, Xu Z, Cristea IM, Kang Y. (2011) Identification of Staphylococcal nuclease domain containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J Biol Chem. 286: 19982-19992.

Matsushima K, Isomoto H, Yamaguchi N, Inoue N, Machida H, Nakayama T, Hayashi T, Kunizaki M, Hidaka S, Nagayasu T, Nakashima M, Ujifuku K, Mitsutake N, Ohtsuru A, Yamashita S, Korpal M, Kang Y, Gregory PA, Goodall GJ, Kohno S, Nakao K. (2011) MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells.J. Transl. Med., 9(1):30.

Shan J, Budjiono SJ, Hu G, Yao N, Kang Y, Ju Y, and Prud'homme RK. (2011) PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenyl porphine (TPP) for photodynamic therapy. Adv. Funct. Mater., 21:2488-2495.

Blanco MA, Kang Y. (2011) Signaling pathways in breast cancer metastasis - novel insights from functional genomics.Breast Cancer Res. 13: 206. 

Sethi N, Dai X, Winter CG, Kang Y. (2011) Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells.Cancer Cell. 19: 192-205.

Tiede B, Kang Y. (2011) From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer.Cell Res. 21: 245-257. 

Tamasi J, Zhang X, Lu X, Zhu J, Chen H, Tian X, Lee T-C, Threadgill DW, Kream BE, Kang Y, Partridge NC, and Qin L. (2011) In vivo epidermal growth factor receptor plays an anabolic role in bone metabolism.J. Bone Miner. Res., 26:1022-34.

2010

Lu X, Kang Y. (2010) Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis.Clin Cancer Res. 16: 5928-5935. 

Sethi N, Yan Y, Quek D, Schupbach T, Kang Y. (2010) Rabconnectin-3 is a functional regulator of mammalian notch signaling.J Biol Chem. 285: 34757-34764.

Sethi N, Kang Y. (2010) Dysregulation of developmental pathways in bone metastasis. Bone. 48: 16-22.

Ganapathy V, Ge R, Grazioli A, Xie W, Banach- Petrosky W, Kang Y, Lonning S, McPherson J, Yingling JM, Biswas S, Mundy GR, and Reiss M. (2010) Targeting the transforming growth factor-β pathway inhibits human basal-like breast cancer metastasis. Mol. Cancer., 9(1):122.

Lu X, Lu X, Kang Y. (2010) Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement. Cell Res. 20: 1012-1022. 

Matveeva O, Kang Y, Nechipurenko YD, Nemtsov VA, Spiridonov AN and Shabalina SA. (2010) Optimization of duplex stability and terminal asymmetry for shRNA design. PLoS One, 5(4): e10180.

Lu X, Yan CH, Yuan M, Wei Y, Hu G, Kang Y. (2010) In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res. 70: 3905-3914. 

Korpal M, Kang Y. (2010) Targeting the transforming growth factor-beta signalling pathway in metastatic cancer. Eur J Cancer. 46: 1232-1240.

Lu X, Bennet B, Mu E, Rabinowitz J, Kang Y. (2010) Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. J Biol Chem. 285: 9317-9321.

2009

Lu X, Kang Y. (2009) Epidermal growth factor signalling and bone metastasis.Br J Cancer. 102: 457-461.

Tiede BJ, Owens LA, Li F, Decoste C, Kang Y. (2009) A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy. PLoS One. 4: e8035.

Lu X, Kang Y. (2009) Metalloproteinases and osteoblast EGFR signaling in osteolytic bone metastasis of breast cancer. Cell Cycle. 8: 3804-3805.

Lu X, Kang Y. (2009) Cell fusion as a hidden force in tumor progression. Cancer Res. 69: 8536-8539.

Hu G, Wei Y, Kang Y. (2009) The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res. 15: 5615-5620.

Lu X, Kang Y. (2009) Chemokine (C-C Motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem. 284: 29087-29096.

Hu G, Kang Y, Wang XF. (2009) From breast to the brain: Unraveling the puzzle of metastasis organotropism. J Mol Cell Biol. 1: 3-5.

Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, Massagué J, Kang Y. (2009) ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev. 23: 1882-1894.

Korpal M, Yan J, Lu X, Xu S, Lerit DA, Kang Y. (2009) Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat Med. 15: 960-966.

Steeg PS, Anderson RL, Bar-Eli M, Chambers AF, Eccles SA, Hunter K, Itoh K, Kang Y, Matrisian LM, Sleeman JP, Theodorescu D, Thompson EW, Welch DR. (2009) Preclinical drug development must consider the impact on metastasis. Clin. Cancer Res., 15:4529-30

Kang Y. (2009) Analysis of cancer stem cell metastasis in xenograft animal models. Methods Mol Biol. 568: 7-19. 

Wei Y, Hu G, and Kang Y. (2009) Metadherin unravels a connection between metastasis and chemoresistance. Cell Cycle, 8(14): 2132-3.

Wei Y, Hu G, Kang Y. (2009) Metadherin as a link between metastasis and chemoresistance. Cell Cycle. 8: 2132-2133. 

Lu X, Kang Y. (2009) Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci. 106: 9385-9390.

Korpal M, Kang Y. (2009) The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol. 5: 115-119.

Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL, Haffty BG, Kang Y. (2009) MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell. 15: 9-20. 

2005-2008

Korpal M, Lee ES, Hu G, Kang Y. (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 283: 14910-14914.

Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L. (2007) EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: Implications for osteolytic bone metastases. J Biol Chem 282: 26656-26664.

Lu X, Kang Y. (2007) Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia 12: 153-162.

Kang Y. (2007) New tricks against an old foe: molecular dissection of metastasis tissue tropism in breast cancer. Breast Dis 26: 129-138. 

Li F, Tiede B, Massague J, Kang Y. (2006) Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 17: 3-14.

Kang Y. (2006) Pro-metastasis function of TGFbeta mediated by the smad pathway. J Cell Biochem 98: 1380-1390.

Gupta GP, Minn AJ, Kang Y, Siegel PM, Serganova I, Cordon-Cardo C, Olshen AB, Gerald WL, Massague J. (2005) Identifying Site-specific Metastasis Genes and Functions. Cold Spring Harb Symp Quant Biol 70: 149-158.

Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R, Massague J. (2005) Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest 115: 44-55.

Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen C, Manova-Todorava K, Blasberg R, Gerald WL, Massagué J. (2005) Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA 102: 13909-13914.

Kang Y. (2005) Functional genomic analysis of cancer metastasis: biologic insights and clinical implications. Expert Rev Mol Diagn 5: 385-395.

1998-2004

Kang Y, Massague J. (2004) Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277-279.

Bodem J, Kang Y, Flugel RM. (2004) Comparative functional characterization of the feline foamy virus transactivator reveals its species specificity. Virology 318: 32-36.

Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C, Guise TA, Massague J. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3: 537-549.

Kang Y, Chen CR, Massague J. (2003) A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 11: 915-926.

Xu L, Kang Y, Col S, Massague J. (2002). Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell 10: 271-282.

Wiegand HL, Coburn GA, Zeng Y, Kang Y, Bogerd HP, Cullen BR. (2002) Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Mol Cell Biol 22: 245-256.

Ho DN, Coburn GA, Kang Y, Cullen BR, Georgiadis MM. (2002) The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. Proc Natl Acad Sci USA 99: 1888-1893.

Chen CR, Kang Y, Siegel PM, Massague J. (2002) E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 110: 19-32.

Coburn GA, Wiegand HL, Kang Y, Ho DN, Georgiadis MM, Cullen BR. (2001) Using viral species specificity to define a critical protein/RNA interaction surface. Genes Dev 15: 1194-1205.

Chen CR, Kang Y, Massague J. (2001) Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci USA 98: 992-999.PubMed

Neufeld KL, Nix DA, Bogerd H, Kang Y, Beckerle MC, Cullen BR, White RL. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci USA 97: 12085-12090.

Kang Y, Bogerd HP, Cullen BR. (2000) Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element. J Virol 74: 5863-5871.

Truant R, Kang Y, Cullen BR. (1999) The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function. J Biol Chem 274: 32167-32171.

Kang Y, Cullen BR. (1999) The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev 13: 1126-1139. PubMed

Kang Y, Bogerd HP, Yang J, Cullen BR. (1999) Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor. Virology 262: 200-209.

Kang Y, Cullen BR. (1998) Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1. J Virol 72: 5502-5509.

Kang Y, Blair WS, Cullen BR. (1998) Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter. J Virol 72: 504-511.