Hughson Lab

Hughson Lab Publications

Recent Publications

Baker RW, Jeffrey PD, Zick M, Phillips BP, Wickner WT, Hughson FM. (2015) A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science 349(6252): 1111-4.

Rogers JV, McMahon C, Baryshnikova A, Hughson FM, Rose MD. (2014) ER-associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic ER fusion pathway. Mol Biol Cell. 25: 3401-12.

Ha JY, Pokrovskaya ID, Climer LK,...Hughson FM. (2014) Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Proc Natl Acad Sci. 111: 15762-7.

Bharucha N, Liu Y, Papanikou E,...Hughson FM, Glick BS. (2013) Sec16 influences transitional ER sites by regulating rather than organizing COPII. Mol Biol Cell. 24: 3406-19.

Baker R.W., Jeffrey P.D., Hughson F.M. (2013) Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16 Plos One 2013 Jun 26;8(6):e67409.

Hughson FM. (2013) Chaperones that SNARE neurotransmitter release. Science. 339: 406-07.

McMahon C., Studer S.M., Clendinen C., Dann G.P., Jeffrey P.D., Hughson F.M. (2012) The structure of Sec12 implicates potassium ion coordination in Sar1 activation. J Biol Chem. 2012 Dec 21;287(52):43599-606.

Chen G., Swem L.R., Swem D.L., Stauff D.L., O'Loughlin C.T., Jeffrey P.D., Bassler B.L., Hughson F.M. (2011) A strategy for antagonizing quorum sensing. Mol Cell. 42, 199-209.


Lees, J.A., Yip, C.K., Walz, T., and Hughson, F.M. (2010) Molecular organization of the COG vesicle tethering complex. Nat. Struct. Mol. Biol. 17, 1292-7.

Yu, I.M., and Hughson, F.M. (2010) Tethering factors as organizers of intracellular vesicular traffic. Annu. Rev. Cell. Dev. Biol. 26, 137-156.

Hughson, F.M., and Reinisch, K.M. (2010) Structure and mechanism in membrane trafficking. Curr Opin Cell Biol. 22, 454-460.

Ren, Y., Yip, C.K., Tripathi, A., Huie, D., Jeffrey, P.D., Walz, T., and Hughson F.M. (2009) A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell 139, 1119-1129.

Kelly, R.C., Bolitho, M.E., Higgins, D.A., Lu, W., Ng, W.L., Jeffrey, P.D., Rabinowitz, J.D., Semmelhack, M.F., Hughson, F.M., and Bassler, B.L. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat. Chem. Biol. 5, 891-895.

Richardson, B.C., Smith, R.D., Ungar, D., Nakamura, A., Jeffrey, P.D., Lupashin, V.V., and Hughson, F.M. (2009) Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proc. Natl. Acad. Sci. U.S.A. 106, 13329-13334

Tripathi, A., Ren, Y., Jeffrey, P.D., and Hughson, F.M. (2009) Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nature Struct. Molec. Biol. 16, 114-123.

Hughson, F.M. (2008) Both layers of the COPII coat come into view [Preview]. Cell 134, 384-385.

Cavanaugh, L.F., Chen, X., Richardson, B.C., Ungar, D., Pelczer, I., Rizo, J., and Hughson, F.M. (2007)Structural analysis of conserved oligomeric Golgi complex subunit 2. J. Biol. Chem. 282, 23418-23426.

Neiditch, M.B. and Hughson, F.M. (2007) The regulation of histidine sensor kinase complexes by quorum sensing signal molecules. Meth. Enzymol. 423, 250-263.

Neiditch, M.B., Federle, M.J., Pompeani, A.J., Kelly, R.C., Swem, D.L., Jeffrey, P.D., Bassler, B.L., and Hughson, F.M. (2006) Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell 126, 1095-1108.

Togneri, J., Cheng, Y.S., Munson, M., Hughson, F.M., and Carr, C.M. (2006) SNARE complex binding mode of the Sec1/Munc-18 protein, Sec1p. Proc. Natl. Acad. Sci. USA 103, 17730-17735.

Ungar, D., Oka, T., Krieger, M., and Hughson, F.M. (2006) Retrograde transport on the COG railway [review] Trends Cell Biol. 16, 113-120.

Oka, T., Vasile, E., Penman, M., Novina, C.D., Dykxhoorn, D.M., Ungar, D., Hughson, F.M., Krieger, M. (2005) Genetic analysis of the subunit organization and function of the COG complex: Studies of Cog5 and Cog7 deficient mammalian cells. J. Biol. Chem. 280, 32736-32745.

Ungar, D., Oka, T., Vasile, E., Krieger, M., and Hughson, F.M. (2005) Subunit architecture of the conserved oligomeric Golgi complex. J. Biol. Chem. 280, 32729-32735.

Neiditch, M.B., Federle, M.J., Miller, S.T., Bassler, B.L., and Hughson, F.M. (2005) Regulation of LuxPQ receptor activity by the quorum sensing signal autoinducer-2. Mol. Cell 18, 507-518.