Enquist Lab Members

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Principal Investigator

Lynn W. Enquist
Lynn W. Enquist
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Research Interest:  Genetics and molecular biology of DNA viruses with a special emphasis on neurotropic alpha herpes viruses. Lynn W. Enquist Biography »

Curriculum Vitaepdf-icon-25x25


Postdoctoral Fellows

Jens Bernhard
Jens-Bernhard Bosse
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Research Interest: Jens is interested in how herpesvirus capsids exit the nucleus. He employs high-speed imaging and biophysical methods to measure and characterize how capsid move in the host nucleus.


Esteban
Esteban Engel
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Research Interest: Esteban is interested in studying the mechanism of HSV-1 neuronal transport and neurovirulence.  He wants to identify the essential viral and host proteins required for neuronal spread. He is also developing new viral strains with enhanced neuronal tracing and gene delivery capabilities.


Ian Hogue
Ian Hogue
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Research Interest: Studying the cell biological mechanisms of herpesvirus egress/exocytosis.


Orkide
Orkide Koyuncu
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Research Interest: Orkide is aiming to better understand the molecular mechanisms of the cross-talk between alpha-herpesviruses and host neurons during viral infection. One of the most interesting features of neurons is the presence of local protein synthesis machinery in axons; far away from the cell body. Those locally translated proteins regulate growth cone navigation and integrity during development, regeneration and retrograde communication with the cell body in adult neurons. She is particularly interested in revealing how axonal RNA/protein dynamics are affected during viral infection and whether viruses modulate or utilize such machinery in neurites for efficient transport and spread.


Karen Lancaster
Karen Lancaster
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Research Interest: Karen is interested in the viral spread from the periphery to the central nervous system. Specifically, elucidating the mechanisms of trans-synaptic spread and the neuronal perturbations that accompany this unique cell to cell infection. She is interested in understanding the role of electrical coupling, increased action potential firing, altered intracellular calcium and mitochondrial dynamics from both host and viral standpoints. Additionally, Karen plans to further develop these findings to understand the long term consequences of viral infection on neuronal circuits after the acute phase of infection has been resolved.

 

Julian
Julian Scherer
 
Research Interest:  Julian is interested in microtubule based transport of herpes viruses during entry and egress and the role of molecular motors in infection.

Graduate Students


Alex Geller
Alex Geller
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Research Interest: Alex engineers mutant herpes viruses optimized for neural tracing as well as vectors for gene therapy targeting the brain.


Oliver Hao Huang
Oliver Hao Huang
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Research Interest: One of the interesting phenomenons during PRV neuronal infection is the gradual degradation of KIF1A, the major kinesin motor responsible for PRV axonal anterograde transport. Oliver is trying to find the underlying mechanisms mediating the degradation and the functional significance in PRV axonal transport and egress.


macgibeny
Margaret MacGibeny
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Ren Song
Ren Song

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Research Interest: Ren is interested in the molecular mechanisms of PRV retrograde infection in peripheral nervous system neurons under the influence of host immune responses. Her current research focuses on how neuronal axons respond to pro-inflammatory cytokines and how these responses affect the retrograde transport and replication of PRV.


Shree Tanneti
Shree Tanneti
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Research Interest: Viral infection induces the host cell to activate various signaling pathways. Such cellular responses are hijacked by the virus in its advantage. For example, viruses utilize host machinery to evade immune response, replicate and spread to neighboring cells. I am particularly interested in studying the mechanisms behind viral transport associated cell-signaling within neurons.

 

Undergraduate Students

Zachary Yaffe
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Lab Manager

Halina
Halina Staniszewska Goraczniak
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Administrative Assistant

Matt
Matthew Montondo
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P (609) 258-2664