Faculty & Research
banner_research_labs

Molecular Biology Faculty

Alexei Korennykh

ASSOCIATE Professor of Molecular Biology

Alexei Korennykh

lab Korennykh Research Lab
Phone (609) 258-6071
locationSchultz Lab, 216
Phone Lab (609) 258-6071
Faculty Assistant
anna schmedel
Phone (609) 258-5028

Research Focus

Immune & Stress Response Mediated by RNA

Protein levels in mammalian cells are set largely by the abundance of their messenger RNAs (mRNAs). The mRNA abundance depends on mRNA production and decay, which change according to the needs of the cell. The production is controlled by transcription factors or by chromatin modifications epigenetically, whereas decay is controlled by microRNAs (miRNAs), by proteins that bind to AU-rich RNA elements (AREs) in mRNAs, as well as by poly-U tail addition or m6A methylation.

In addition, mammalian cells contain a variety of sensors that survey conditions inside the cells (DNA damage, viral or bacterial molecules) or outside the cells (cytokines, chemokines, interferons, viral or bacterial molecules), and tune the levels of mRNAs involved in immune and stress programs. These programs either help the cell to adapt to the damage or kill the cell to benefit survival of the whole organism. They are important not only for normal cellular functions, but also for infectious and neoplastic diseases, inflammatory and degenerative disorders, diabetes and innate (i.e. pre-programmed) immunity.

Alexei Korennykh Research»


Awards & Recognition

2014 Burroughs Wellcome Fund Award

2014 Sidney Kimmel Foundation Award

2014 James A. Elkins, Jr. '41 Preceptorship in Molecular Biology, Princeton University

2011 General Biology Research Award, 6th Annual Awards, BioMed Central (London)

2010 UCSF Dean’s Postdoctoral Research Prize and Lecture

2007-2010 Jane Coffin Childs Postdoctoral fellow

2007 Cancer Research Institute (CRI) Postdoctoral fellowship (awarded)

2001-2003 Burroughs Wellcome Graduate fellowship

1995 George Soros International scholarship (ISSEP)


Selected Publications

Donovan J, Whitney G, Rath S, Korennykh A. (2015) Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3. Proc Natl Acad Sci. 112:3949-54. Pubmed

Han Y, Donovan J, Rath S, Whitney G, Chitrakar A, Korennykh A. (2014) Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science. 343:1244-8. Pubmed

Donovan J, Dufner M, Korennykh A. (2013) Structural basis for cytosolic double-stranded RNA surveillance by human OAS1. Proc Natl Acad Sci. 110: 1652-57. PubMed

Han Y, Whitney G, Donovan J, Korennykh A. (2012) Innate immune messenger 2-5A tethers human RNase L into active high-order complexes. Cell Rep. 2: 902-13. Pubmed

Korennykh A1, Walter P. (2012) Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol. 28: 251-77. Pubmed

Korennykh AV, Korostelev AA, Egea PF,...Walter P. (2011) Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 9: 47. PubMed

Korennykh AV, Egea PF, Korostelev AA,...Walter P. (2011) Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 9: 48. PubMed

Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P. (2011) Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J Cell Biol. 193: 171-84. PubMed

Plantinga MJ, Korennykh AV, Piccirilli JA, Correll CC. (2011) The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues. Biochemistry. 50: 3004-13. PubMed

Li H1, Korennykh AV, Behrman SL, Walter P. (2010) Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci. 107: 16113-18. Pubmed

Li H, Korennykh AV, Behrman SL, Walter P. (2010) Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci. 107: 16113-18. PubMed

Korennykh AV, Egea PF, Korostelev AA,...Walter P. (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature. 457: 687-93. PubMed

Aragón T, van Anken E, Pincus D,...Korennykh AV,...Walter P. (2009) Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature. 457: 736-40. PubMed

Plantinga MJ, Korennykh AV, Piccirilli JA, Correll CC. (2008) Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate. Biochemistry. 47: 8912-18. PubMed

Korennykh AV, Plantinga MJ, Correll CC, Piccirilli JA. (2007) Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin. Biochemistry. 46: 12744-56. PubMed

Korennykh AV, Correll CC, Piccirilli JA. (2006) Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins. RNA. 13: 1391-96. PubMed

Korennykh AV, Piccirilli JA, Correll CC. (2006) The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins. Nat Struct Mol Biol. 13: 436-43. PubMed

Shcherbakova T, Korennykh, A, Van Langen L, Sheldon R, Švedas V. (2004) Use of high acyl donor concentrations leads to penicillin acylase inactivation in the course of peptide synthesis. J Molec Catalysis B: Enzymatic. 31: 63-65. Science Direct

Khimiuk A, Korennykh A, Van Langen L, Van Rantwijk F, Sheldon R, Švedas V. (2003) Penicillin acylase-catalyzed peptide synthesis in aqueous medium: a chemo-enzymatic route to stereoisomerically pure diketopiperazines. Tetrahedron: Asymmetry. 14: 3123-28.

 

Upcoming Events

Wed, Sep 14, 2016

Tue, Sep 20, 2016

Wed, Sep 28, 2016

Contact Us

Lewis Thomas Laboratory at Princeton University

119 Lewis Thomas Laboratory
Washington Road, Princeton, NJ  08544-1014

Need help? Contact us

Fax: (609) 258-3980
Website:  molbio.princeton.edu