Faculty & Research

Molecular Biology Faculty

Jeffry B. Stock

Professor of Molecular Biology

Jeffry B. Stock


phone (609) 258-6111
locationLewis Thomas Lab, 148
phone Lab (609) 258-6112
Faculty Assistant
Gail Huber
Phone (609) 258-1894

Research Focus

We are primarily concerned with the development of novel pharmaceuticals to regulate signal transduction pathways that underlie chronic diseases associated with inflammation and aging. The activities of approximately a third of the proteins in vertebrate cells are regulated by reversible phosphorylation at serine and threonine resides. There are almost a thousand different protein kinases, each of which catalyzes the transfer of phosphoryl groups from ATP to a specific set of protein substrates in response to a regulatory input. In contrast, there are just a few phosphoprotein phosphatases to catalyze the removal of these groups. Our research over the past several years has focused on the molecular mechanisms that underlie the regulation of these phosphatases. Through these efforts we have identified potential pharmaceutical targets for the global regulation of phosphatase activity, developed screens for useful therapeutic agents, and characterized pharmaceutical leads that provide a basis for further medicinal chemistry exploration. Our current research is essentially translational, with two principal targets: skin and brain.

The skin project targets inflammatory diseases such as psoriasis, rosacea, atopic dermatitis, and acne as well as the general problem of skin aging. Our brain research is concerned with neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Both projects focus on the regulation and pharmacuetical modulation of the most abundant phosphoprotein phosphatase, phosphoprotein phosphatase 2A (PP2A). Several years ago we discovered that PP2A activity is regulated by reversible carboxyl methylation. This modification is catalyzed by two PP2A-specific converter enzymes, a methyltransferase (PPMT) and a methylesterase (PME). Demethylation is associated with inflammation, apoptosis, and neurodegeneration. We have identified several different pharmaceutical chemotypes that bind to PP2A and inhibit its demethylation by PME. We have shown that one agent, a natural product found in coffee, is efficacious in animal models for neurodegeneration and skin inflammation.

Selected Publications

Fernández JR, Rouzard K,... Stock JB, Stock M, Gordon JS, Pérez E. (2016) In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities. J Cosmet Dermatol. [Epub ahead of print]

Fernandéz JR, ... Stock JB, Stock M, Gordon JS, Pérez E. (2015) Anti-inflammatory and anti-bacterial properties of tetramethylhexadecenyl succinyl cysteine (TSC): a skin-protecting cosmetic functional ingredient.   Int J Cosmet Sci. 37(1):129-33. Pubmed

Basurto-Islas G, Blanchard J, Tung YC,...Stock JB, Iqbal K. (2014) Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease. Neurobiol Aging. 35:2701-12. Pubmed

Stock JB, Zhang S. (2013) The biochemistry of memory. Curr Biol. 23: R741-45. Pubmed

Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y. (2008) Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell. 133: 154-63. PubMed

Baker MD, Stock JB. (2007) Signal transduction: networks and integrated circuits in bacterial cognition. Curr Biol. 17: R1021-24. PubMed

Chen Y, McQuade KJ, Guan XJ,...Stock JB, Cox EC. (2007) Isoprenylcytseine carboxyl methylation is essential for development in Dictyostelium discoideum. Mol Biol Cell. 18: 4106-18. PubMed

Chen Y, Xu Y, Bao Q,...Stock JB,...Shi Y. (2007) Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40. Nat Struct Mol Biol. 6: 527-34. PubMed

Xing Y, Xu Y, Chen Y,...Stock JB, Shi Y. (2006) Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell. 127: 341-53. PubMed

Chao Y, Xing Y, Chen Y,...Stock JB, Shi Y. (2006) Structure and mechanism of the phosphotyrosyl phosphatase activator. Mol Cell. 23: 535-46. PubMed

Wolanin PM, Baker MD, Francis NR, Thomas DR, Derosier DJ, Stock JB. (2006) Self-assembly of receptor/signaling complexes in bacterial chemotaxis. Proc Natl Acad Sci. 103: 14313-18. PubMed

Thomason PA, Sawai S, Stock JB, Cox EC. (2006) The histidine kinase homologue DhkK/Sombrero controls morphogenesis in Dictyostelium. Dev Biol. 292: 358-70. PubMed

Baker M, Wolanin P, Stock J. (2005) Systems biology of bacterial chemotaxis. Curr Opin Microbiol. 9: 187-92. PubMed

Baker M, Wolanin P, Stock J. (2005) Signal transduction in bacterial chemotaxis. Bioessays. 28: 9-22. PubMed

Wolanin PM, Stock JB. (2004) Bacterial chemosensing: cooperative molecular logic. Curr Biol. 14: R486-87. PubMed

Webre DJ, Wolanin PM, Stock JB. (2004) Modulated receptor interactions in bacterial transmembrane signaling. Trends Cell Biol. 14: 478-82. PubMed

Francis NR, Wolanin PM, Stock JB, Derosier DJ, Thomas DR. (2004) Three-dimensional structure and organization of a receptor/signaling complex. Proc Natl Acad Sci. 101: 17480-85. PubMed

Wolanin PM, Webre DJ, Stock JB. (2003) Mechanism of phosphatase activity in the chemotaxis response regulator CheY. Biochemistry. 42: 14075-82. PubMed

Webre DJ, Wolanin PM, Stock JB. (2003) Bacterial chemotaxis. Curr Biol. 13: R47-49. PubMed

Park S, Wolanin PM, Yuzbashyan EA, Silberzan P, Stock JB, Austin RH. (2003) Motion to form a quorum. Science. 301: 188. PubMed

Park S, Wolanin PM, Yuzbashyan EA,...Stock JB,...Austin R. (2003) Influence of topology on bacterial social interaction. Proc Natl Acad Sci. 100: 13910-15. PubMed

Napper S, Wolanin PM, Webre DJ, Kindrachuk J, Waygood B, Stock JB. (2003) Intramolecular rearrangements as a consequence of the dephosphorylation of phosphoaspartate residues in proteins. FEBS Lett. 538: 77-80. PubMed

Wolanin PM, Thomason PA, Stock JB. (2002) Histidine protein kinases: key signal transducers outside the animal kingdom. Genome Biol. 3: REVIEWS3013. PubMed

Vafai SB, Stock JB. (2002) Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. FEBS Lett. 518: 1-4. PubMed

Thomason PA, Wolanin PM, Stock JB. (2002) Signal transduction: receptor clusters as information processing arrays. Curr Biol 12: R399-401. PubMed

Stock JB, Levit MN, Wolanin PM. (2002) Information processing in bacterial chemotaxis. Sci STKE 2002: PE25. PubMed

Levit MN, Stock JB. (2002) Receptor methylation controls the magnitude of stimulus-response coupling in bacterial chemotaxis. J Biol Chem. 277: 36760-65. PubMed

Levit MN, Grebe TW, Stock JB. (2002) Organization of the receptor-kinase signaling array that regulates Escherichia coli chemotaxis. J Biol Chem. 277: 36748-54. PubMed

Levit MN, Abramczyk BM, Stock JB, Postel EH. (2002) Interactions between Escherichia coli nucleoside-diphosphate kinase and DNA. J Biol Chem. 277: 5163-67. PubMed

Francis NR, Levit MN, Shaikh TR, Melanson LA, Stock JB, DeRosier DJ. (2002) Subunit organization in a soluble complex of tar, CheW, and CheA by electron microscopy. J Biol Chem. 277: 36755-59. PubMed

Da Re S, Tolstykh T, Wolanin PM, Stock JB. (2002) Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism. Protein Sci. 11: 2644-54. PubMed

Mourey L, Da Re S, Pedelacq JD,...Stock JB, Samama JP. (2001) Crystal structure of the CheA histidine phosphotransfer domain that mediates response regulator phosphorylation in bacterial chemotaxis. J Biol Chem. 276: 31074-82. PubMed

Wu J, Tolstykh T, Lee J, Boyd K, Stock JB, Broach JR. (2000) Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo. EMBO J. 19: 5672-81. PubMed

Tolstykh T, Lee J, Vafai S, Stock JB. (2000) Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits. EMBO J. 19: 5682-91. PubMed

Stock J, Levit M. (2000) Signal transduction: hair brains in bacterial chemotaxis. Curr Biol. 10: R11-14. PubMed

Stock J, Da Re S. (2000) Signal transduction: response regulators on and off. Curr Biol. 10: R420-24. PubMed

Thomason PA, Traynor D, Stock JB, Kay RR. (1999) The RdeA-RegA system, a eukaryotic phospho-relay controlling cAMP breakdown. J Biol Chem. 274: 27379-84. PubMed

Stock J, Da Re S. (1999) A receptor scaffold mediates stimulus-response coupling in bacterial chemotaxis. Cell Calcium. 26: 157-64. PubMed

Stock J. (1999) Sensitivity, cooperativity and gain in chemotaxis signal transduction. Trends Microbiol. 7: 1-4. PubMed

Stock J. (1999) Signal transduction: Gyrating protein kinases. Curr Biol. 9: R364-67. PubMed

Levit MN, Stock JB. (1999) pH sensing in bacterial chemotaxis. Novartis Found Symp. 221: 38-50; discussions 50-54. PubMed

Levit MN, Liu Y, Stock JB. (1999) Mechanism of CheA protein kinase activation in receptor signaling complexes. Biochemistry. 38: 6651-58. PubMed

Hakenbeck R, Grebe T, Zahner D, Stock JB. (1999) beta-lactam resistance in Streptococcus pneumoniae: penicillin-binding proteins and non-penicillin-binding proteins. Mol Microbiol. 33: 673-78. PubMed

Grebe TW, Stock JB. (1999) The histidine protein kinase superfamily. Adv Microb Physiol. 41: 139-227. PubMed

Elowitz MB, Surette MG, Wolf PE, Stock JB, Leibler S. (1999) Protein mobility in the cytoplasm of Escherichia coli. J Bacteriol. 181: 197-203. PubMed

Da Re SS, Deville-Bonne D, Tolstykh T, M Vr, Stock JB. (1999) Kinetics of CheY phosphorylation by small molecule phosphodonors. FEBS Lett. 457: 323-26. PubMed

Levit MN, Liu Y, Stock JB. (1998) Stimulus response coupling in bacterial chemotaxis: receptor dimers in signalling arrays. Mol Microbiol. 30: 459-66. PubMed

Grebe TW, Stock J. (1998) Bacterial chemotaxis: the five sensors of a bacterium. Curr Biol. 8: R154-57. PubMed

Alon U, Camarena L, Surette MG,...Stock J. (1998) Response regulator output in bacterial chemotaxis. EMBO J. 17: 4238-48. PubMed

Liu Y, Levit M, Lurz R, Surette MG, Stock JB. (1997) Receptor-mediated protein kinase activation and the mechanism of transmembrane signaling in bacterial chemotaxis. EMBO J. 16: 7231-40. PubMed

Elowitz MB, Surette MG, Wolf PE, Stock J, Leibler S. (1997) Photoactivation turns green fluorescent protein red. Curr Biol. 7: 809-12. PubMed

Zahner D, Grebe T, Guenzi E,...Stock JB, Hakenbeck R. (1996) Resistance determinants for beta-lactam antibiotics in laboratory mutants of Streptococcus pneumoniae that are involved in genetic competence. Microb Drug Resist. 2: 187-91. PubMed

Surette MG, and Stock JB. (1996) Role of alpha-helical coiled-coil interactions in receptor dimerization, signaling, and adaptation during bacterial chemotaxis. J Biol Chem. 271: 17966-73. PubMed

Surette MG, Levit M, Liu Y,...Stock JB. (1996) Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis. J Biol Chem. 271: 939-45. PubMed

Stock J. (1996) Receptor signaling: dimerization and beyond. Curr Biol. 6: 825-27. PubMed

Levit M, Liu Y, Surette M, Stock J. (1996) Active site interference and asymmetric activation in the chemotaxis protein histidine kinase CheA. J Biol Chem. 271: 32057-63. PubMed

Lee J, Chen Y, Tolstykh T, Stock J. (1996) A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. Proc Natl Acad Sci. 93: 6043-47. PubMed

Hakenbeck R, Stock JB. (1996) Analysis of two-component signal transduction systems involved in transcriptional regulation. Methods Enzymol. 273: 281-300. PubMed

de Jonge R, Teixeira de Mattos MJ, Stock JB, Neijssel OM. (1996) Pyrroloquinoline quinone, a chemotactic attractant for Escherichia coli. J Bacteriol. 178: 1224-26. PubMed

Volker C, Stock JB. (1995) Carboxyl methylation of Ras-related proteins. Methods Enzymol. 255: 65-82. PubMed

Volker C, Pillinger MH, Philips MR, Stock JB. (1995) Prenylcysteine analogs to study function of carboxylmethylation in signal transduction. Methods Enzymol. 250: 216-25. PubMed

Regazzi R, Sasaki T, Takahashi K,...Stock JB,...Wollheim CB. (1995) Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide. Biochim Biophys Acta. 1268: 269-78. PubMed

Philips MR, Staud R, Pillinger M,...Stock JB, Weissmann G. (1995) Activation-dependent carboxyl methylation of neutrophil G-protein gamma subunit. Proc Natl Acad Sci. 92: 2283-87. PubMed

Stock J, Surette M, Park P. (1994) Chemosensing and signal transduction in bacteria. Curr Opin Neurobiol. 4: 474-80. PubMed

Stock J, Surette M. (1994) Bacterial chemotaxis. The motor connection. Curr Biol. 4: 143-44. PubMed

Pillinger MH, Volker C, Stock JB, Weissmann G, Philips MR. (1994) Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils. J Biol Chem. 269: 1486-92. PubMed

McCleary WR, Stock JB. (1994) Acetyl phosphate and the activation of two-component response regulators. J Biol Chem. 269: 31567-72. PubMed

Floer M, Stock J. (1994) Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid. Biochem Biophys Res Commun. 198: 372-79. PubMed

Stock J. (1993) Protein phosphorylation: phosphoprotein talk. Curr Biol. 3: 303-05. PubMed

Stock AM, Martinez-Hackert E, Rasmussen BF,...Stock JB,...Petsko GA. (1993) Structure of the Mg(2+)-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis. Biochemistry. 32: 13375-80. PubMed

Philips MR, Pillinger MH, Staud R,...Stock JB. (1993) Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils. Science. 259: 977-80. PubMed

Metz SA, Rabaglia ME, Stock JB, Kowluru A. (1993) Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. Biochem J. 295 (Pt 1): 31-40. PubMed

McCleary WR, Stock JB, Ninfa AJ. (1993) Is acetyl phosphate a global signal in Escherichia coli? J Bacteriol. 175: 2793-98. PubMed

Lukat GS, Stock JB. (1993) Response regulation in bacterial chemotaxis. J Cell Biochem. 51: 41-46. PubMed

Lee J, Stock J. (1993) Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase. J Biol Chem. 268: 19192-95. PubMed

DeKoster GT, Robertson AD, Stock AM, Stock JB. (1993) Urea and guanidine-HCl yield different unfolding free energies for CheY: Which denaturant provides the most reliable free energy values? Tech Prot Chem. IV: 533-40.

Akbar H, Wang W, Kornhauser R, Volker C, Stock JB (1993) Protein prenylcysteine analog inhibits agonist-receptor-mediated signal transduction in human platelets. Proc Natl Acad Sci. 90: 868-72.

Stock JB, Surette MG, McCleary WR, Stock AM. (1992) Signal transduction in bacterial chemotaxis. J Biol Chem. 267: 19753-56. PubMed

Nathke IS, Heuser J, Lupas A, Stock J, Turck CW, Brodsky FM. (1992) Folding and trimerization of clathrin subunits at the triskelion hub. Cell. 68: 899-910. PubMed

Lupas AN, Lupas JM, Stock JB. (1992) Do G protein subunits associate via a three-stranded coiled coil? FEBS Lett. 314: 105-08. PubMed

Lukat GS, McCleary WR, Stock AM, Stock JB (1992) Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors. Proc Natl Acad Sci. 89: 718-22. PubMed

Krueger JK, Stock J, Schutt CE. (1992) Evidence that the methylesterase of bacterial chemotaxis may be a serine hydrolase. Biochim Biophys Acta. 1119: 322-26. PubMed

Feng J, Atkinson MR, McCleary W, Stock JB, Wanner BL, Ninfa AJ. (1992) Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli. J Bacteriol. 174: 6061-70. PubMed

Camps M, Hou C, Sidiropoulos D, Stock JB, Jakobs KH, Gierschik P (1992) Stimulation of phospholipase C by guanine-nucleotide-binding protein beta gamma subunits. Eur J Biochem. 206: 821-31. PubMed

Volker C, Miller RA, McCleary WR,...Stock JB. (1991) Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction. J Biol Chem. 266: 21515-22. PubMed

Volker C, Lane P, Kwee C, Johnson M, Stock J. (1991) A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett. 295: 189-94. PubMed

Stock JB, Lukat GS, Stock AM. (1991) Bacterial chemotaxis and the molecular logic of intracellular signal transduction networks. Annu Rev Biophys Biophys Chem. 20: 109-36. PubMed

Stock J. (1991) Balancing effector outputs. Curr Biol. 1: 154-56. PubMed

Ninfa EG, Stock A, Mowbray S, Stock J. (1991) Reconstitution of the bacterial chemotaxis signal transduction system from purified components. J Biol Chem. 266: 9764-70. PubMed

Lupas A, Van Dyke M, Stock J. (1991) Predicting coiled coils from protein sequences. Science. 252: 1162-64. PubMed

Lukat GS, Lee BH, Mottonen JM, Stock AM, Stock JB. (1991) Roles of the highly conserved aspartate and lysine residues in the response regulator of bacterial chemotaxis. J Biol Chem. 266: 8348-54. PubMed

Stock JB, Stock AM, Mottonen JM. (1990) Signal transduction in bacteria. Nature. 344: 395-400. PubMed

Stock J. (1990) A membrane receptor kinase that regulates development in Bacillus subtilis. Bioessays. 12: 387-88. PubMed

Stimmel JB, Deschenes RJ, Volker C, Stock J, Clarke S (1990) Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein. Biochemistry. 29: 9651-59. PubMed

Olmedo G, Ninfa EG, Stock J, Youngman P. (1990) Novel mutations that alter the regulation of sporulation in Bacillus subtilis. Evidence that phosphorylation of regulatory protein SpoOA controls the initiation of sporulation. J Mol Biol. 215: 359-72. PubMed

Lukat GS, Stock AM, Stock JB. (1990) Divalent metal ion binding to the CheY protein and its significance to phosphotransfer in bacterial chemotaxis. Biochemistry. 29: 5436-42. PubMed

Stock JB, Ninfa AJ and Stock AM (1989) Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol Rev 53: 450-490. PubMed

Stock AM, Mottonen JM, Stock JB, Schutt CE. (1989) Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis. Nature. 337: 745-49. PubMed

Lupas A, Stock J. (1989) Phosphorylation of an N-terminal regulatory domain activates the CheB methylesterase in bacterial chemotaxis. J Biol Chem. 264: 17337-42. PubMed

Krueger JK, Kulke MH, Schutt C, Stock JB. (1989) Protein inclusion body formation and purification. BioPharm. 2: 40-45.

Igo MM, Ninfa AJ, Stock JB, Silhavy TJ. (1989) Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor. Genes Dev. 3: 1725-34. PubMed

Deschenes RJ, Stimmel JB, Clarke S, Stock J, Broach JR. (1989) RAS2 protein of Saccharomyces cerevisiae is methyl-esterified at its carboxyl terminus. J Biol Chem. 264: 11865-73.  PubMed

Wylie D, Stock A, Wong CY, Stock J. (1988) Sensory transduction in bacterial chemotaxis involves phosphotransfer between Che proteins. Biochem Biophys Res Commun. 151: 891-96. PubMed

Stock AM, Wylie DC, Mottonen JM,...Stock JB. (1988) Phospho-proteins involved in bacterial signal transduction. Cold Spring Harbor Symp Quant Biol. 53: 49-57. PubMed

Stock A, Chen T, Welsh D, Stock J. (1988) CheA protein, a central regulator of bacterial chemotaxis, belongs to a family of proteins that control gene expression in response to changing environmental conditions. Proc Natl Acad Sci. 85: 1403-07. PubMed

Ninfa AJ, Ninfa EG, Lupas AN, Stock A, Magasanik B, Stock J. (1988) Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. Proc Natl Acad Sci. 85: 5492-96. PubMed

Clarke S, Vogel JP, Deschenes RJ, Stock J. (1988) Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases. Proc Natl Acad Sci. 85: 4643-47. PubMed

Stock JB, Stock AM. (1987) What is the role of receptor methylation in bacterial chemotaxis? Trends Biochem. Sci. 12: 371-75.

Stock J. (1987) Mechanisms of receptor function and the molecular biology of information processing in bacteria. Bioessays. 6: 199-203. PubMed

Stock AM, Stock JB. (1987) Purification and characterization of the CheZ protein of bacterial chemotaxis. J Bacteriol. 169: 3301-11. PubMed

Stock A, Schaeffer E, Koshland DE Jr, Stock J. (1987) A second type of protein methylation reaction in bacterial chemotaxis. J Biol Chem. 262: 8011-14. PubMed

Stock A, Mottonen J, Chen T, Stock J. (1987) Identification of a possible nucleotide binding site in CheW, a protein required for sensory transduction in bacterial chemotaxis. J Biol Chem. 262: 535-37. PubMed

Stock A, Clarke S, Clarke C, Stock J. (1987) N-terminal methylation of proteins: structure, function and specificity. FEBS Lett. 220: 8-14. PubMed

Simms SA, Stock AM, Stock JB. (1987) Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria. J Biol Chem. 262: 8537-43. PubMed

Simms SA, Cornman EW, Mottonen J, Stock J. (1987) Active site of the enzyme which demethylates receptors during bacterial chemotaxis. J Biol Chem. 262: 29-31. PubMed

Borczuk A, Stock A, Stock J. (1987) S-adenosylmethionine may not be essential for signal transduction during bacterial chemotaxis. J Bacteriol. 169: 3295-300. PubMed

Borczuk A, Staub A, Stock J. (1986) Demethylation of bacterial chemoreceptors is inhibited by attractant stimuli in the complete absence of the regulatory domain of the demethylating enzyme. Biochem Biophys Res Commun. 141: 918-23. PubMed

Stock J, Kersulis G, Koshland DE Jr. (1985) Neither methylating nor demethylating enzymes are required for bacterial chemotaxis. Cell. 42: 683-90. PubMed

Stock J, Borczuk A, Chiou F, Burchenal JE. (1985) Compensatory mutations in receptor function: a reevaluation of the role of methylation in bacterial chemotaxis. Proc Natl Acad Sci. 82: 8364-68. PubMed

Stock A, Koshland DE Jr, Stock J. (1985) Homologies between the Salmonella typhimurium CheY protein and proteins involved in the regulation of chemotaxis, membrane protein synthesis, and sporulation. Proc Natl Acad Sci. 82: 7989-93. PubMed

Simms SA, Keane MG, Stock J. (1985) Multiple forms of the CheB methylesterase in bacterial chemosensing. J Biol Chem. 260: 10161-68. PubMed

Stock JB, Clarke S, Koshland DE Jr. (1984) The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis. Methods Enzymol. 106: 310-21. PubMed

Snyder MA, Stock JB, Koshland DE Jr. (1984) Carboxylmethyl esterase of bacterial chemotaxis. Methods Enzymol. 106: 321-30. PubMed

Stock JB, Waygood EB, Meadow ND, Postma PW, Roseman S. (1982) Sugar transport by the bacterial phosphotransferase system. The glucose receptors of the Salmonella typhimurium phosphotransferase system. J Biol Chem. 257: 14543-52. PubMed

Koshland DE Jr, Goldbeter A, Stock JB. (1982) Amplification and adaptation in regulatory and sensory systems. Science. 217: 220-25. PubMed

Stock JB, Maderis AM, Koshland DE Jr. (1981) Bacterial chemotaxis in the absence of receptor carboxylmethylation. Cell. 27: 37-44. PubMed

Stock JB, Koshland DE, Jr. (1981) Changing reactivity of receptor carboxyl groups during bacterial sensing. J Biol Chem. 256: 10826-33. PubMed

Stock JB, Koshland DE Jr. (1981) A cyclic mechanism for excitation and adaptation. Curr Top Cell Regul. 18: 505-17. PubMed

Snyder MA, Stock JB, Koshland DE Jr. (1981) Role of membrane potential and calcium in chemotactic sensing by bacteria. J Mol Biol. 149: 241-57. PubMed

Postma PW, Stock JB. (1980) Enzymes II of the phosphotransferase system do not catalyze sugar transport in the absence of phosphorylation. J Bacteriol. 141: 476-84. PubMed

Stock JB, Koshland DE Jr. (1978) A protein methylesterase involved in bacterial sensing. Proc Natl Acad Sci. 75: 3659-63. PubMed

Stock JB, Rauch B, Roseman S. (1977) Periplasmic space in Salmonella typhimurium and Escherichia coli. J Biol Chem. 252: 7850-61. PubMed

Stock J, Roseman S. (1971) A sodium-dependent sugar co-transport system in bacteria. Biochem Biophys Res Commun. 44: 132-38. PubMed

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