Faculty & Research
banner_research_labs

Howard A. Stone

Donald R. Dixon ’69 and Elizabeth W. Dixon Professor in Mechanical and Aerospace Engineering and Chair

Howard Stone

This email address is being protected from spambots. You need JavaScript enabled to view it.
D328 Engineering Quad
locationD326 Engineering Quad
 
Phone (609) 258-9493
Phone Lab (609) 258-9015

Research Focus

My group does research in fluid dynamics of "complex fluids", which refers to fluid systems that contain suspended objects (e.g. cells, droplets) that modify the flow. We interact broadly with other researchers in engineering, physics, chemistry and biology. In recent years my group has worked on several problems involving (I) flow and bacteria and (II) flow and biofilms, as well as various problems involving (III)  flow of red bloods cells and (IV) some problems involving chemical signaling of mammalian cells. As part of these studies we have developed expertise with these systems and have forged excellent collaborations with leading labs in molecular biology. For example, in our research we have documented the formation of biofilm streamers in laminar flows, identified shear-enhanced adhesion of Pseudomonas aeruginosa (PA) to surfaces, and the upstream migration of PA when the bacteria is attached to surfaces and exposed to flow. We have also worked on a variety of problems involving mammalian cells, including their response to chemical signals and how the response is influenced by the mechanical properties of the surrounding materials and/or substrate. In all of these studies we have used the toolboxes of microfluidics and microscopy to develop experimental tools appropriate to the questions under study.


Selected Publications

A. Persat, H.A. Stone and Z. Gitai 2014 The curved shape of Caulobacter crescentus enhances surface colonization. Nature Communications. 5. Selected for Nature Communications Biology Selections.

M.Y. Kim, K. Drescher, O.S. Pak, B. Bassler and H.A. Stone 2014 Filaments in curved flow: Rapid formation of Staphylococcus aureus biofilm streamers. New Journal of Physics 16, 065024.

K. Drescher, Y. Shen, B. Bassler and H.A. Stone 2013 Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems. PNAS  110, 4345-4350. Highlighted in the issue and on the NSF website.

A.B. Subramaniam, G. Guidotti, V. Manoharan, and H.A. Stone 2012 Glycans pattern the phase behavior of lipid membranes. Nature Materials 12, 128-133. Highlighted with a commentary.

B. Sun, J. Lembong, M. Rogers, V. Normand and H.A. Stone 2012 Spatial-temporal dynamics of collective chemosensing. PNAS 109, 7753-7758.

Y. Shen, A. Siryaporn, S. Lecuyer, Z. Gitai and H.A. Stone 2012 Flow directs surface-attached bacteria to twitch upstream. Biophysical Journal 103, 146-151.

S. Lecuyer, R. Rusconi, Y. Shen, A. Forsyth, H. Vlamakis, R. Kolter and H.A. Stone 2011 Shear stress increases the residence time of adhesion of Pseudomonas aeruginosa. Biophysical Journal 100, 341-350; corrigendum 100, 1381.

R. Rusconi, S. Lecuyer, L. Guglielmini and H.A. Stone 2010 Laminar flow around corners triggers the formation of bacterial streamers. Journal of the Royal Society Interface. 7, 1293-1299.

MolBio Events

Mon, Nov 03, 2014

Wed, Nov 05, 2014

Thu, Nov 06, 2014

Mon, Nov 10, 2014

Contact Us

Lewis Thomas Laboratory at Princeton University

119 Lewis Thomas Laboratory
Washington Road, Princeton, NJ  08544-1014

Need help? Contact us

Fax: (609) 258-3980
Website:  molbio.princeton.edu