Princeton University Molecular Biology - Molecular Biology Events http://molbio.princeton.edu Thu, 29 Jan 2015 20:58:07 -0500 Joomla! - Open Source Content Management en-gb Joseph Mougous (U Washington) http://molbio.princeton.edu/events/event/363-mougous http://molbio.princeton.edu/events/event/363-mougous Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Feb 04, 2015 - Wed, Feb 04, 2015
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Butler Seminar Series

Speaker
joseph mougous
Joseph Mougous, Ph.D.
University of Washington

Joseph received his undergraduate degree at Western Washington University, Bellingham, where he studied surface chemistry. He then earned his Ph.D. at the University of California, Berkeley, where he worked in Carolyn Bertozzi’s laboratory studying sulfated glycolipids of Mycobacterium tuberculosis. After completing his graduate studies, Joseph joined the laboratory of John Mekalanos at Harvard Medical School, where he characterized a type VI secretion system of Pseudomonas aeruginosa. Joseph established his laboratory at the University of Washington in 2008.

Seminar Topic

 
New insights into toxins and pathways mediating interbacterial interactions

Though they are by definition single-celled organisms, bacteria can exhibit properties more often ascribed to multicellular life. Our group aims to identify, characterize, and eventually, exploit, pathways that bacteria use for intercellular communication and competition. In this presentation, I will discuss our recent progress toward understanding the diversity of mechanisms by which antibacterial toxins delivered by the type VI secretion system act upon recipient cells. I will also describe our discovery that a conserved signaling pathway allows cells of the Gram-negative opportunistic pathogen Pseudomonas aeruginosa to mount a coordinated response to antagonism by competing bacteria.
 

Research lab


http://faculty.washington.edu/mougous

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Sreekanth Chalasani (UC, San Diego) http://molbio.princeton.edu/events/event/364-chalasani http://molbio.princeton.edu/events/event/364-chalasani Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Feb 11, 2015 - Wed, Feb 11, 2015
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Butler Seminar Series

Speaker
chalasani
Sreekanth Chalasani, Ph.D.
University of California, San Diego
Salk Institute for Biological Studies 

Dr. Sreekanth Chalasani is Assistant Professor of Molecular Neurobiology at the Salk Institute for Biological Studies, University of California, San Diego.  Dr. Chalasani received his B.S. from Osmania University, India and his Ph.D. from the University of Pennsylvania.   His lab's research focuses on how neural circuits decode environmental changes and drive behaviors. The lab uses the nematode, C. elegans and zebrafish as models to study brain functions.

Seminar Topic

 
TBA
 

Research lab


http://www.salk.edu/labs/chalasani

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Oliver Hobert (Columbia) http://molbio.princeton.edu/events/event/365-hobert http://molbio.princeton.edu/events/event/365-hobert Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Feb 18, 2015 - Wed, Feb 18, 2015
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Butler Seminar Series

Speaker
Oliver
Oliver Hobert, Ph.D.
Columbia University Medical Center

Oliver Hobert is professor of biochemistry and molecular biophysics at Columbia University.  Dr. Hobert received his Ph.D. from Max Planck Institute for Biochemistry. The main focus of his laboratory is to understand the molecular mechanisms that generate the astounding diversity of cell types in a nervous system.

Seminar Topic

Hobert.Cover-art-3.NN2989-924x763
Gene regulatory mechanisms instructing nervous system development



Research lab

http://hobertlab.org

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Bill Hait (Janssen Research and Development) http://molbio.princeton.edu/events/event/402-hait http://molbio.princeton.edu/events/event/402-hait Location: Lewis Thomas Lab, 003 - Princeton
Category: CSO Seminar Series
Date: Mon, Feb 23, 2015 - Mon, Feb 23, 2015
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Molecular Biology Chief Scientific Officer Seminar Series
presents the G. S. Beckwith Gilbert ’63 Lecture

Speaker
Bill Hait
Bill Hait
Global Head
Janssen Research and Development
Johnson & Johnson


 

Seminar Topic

 TBA

Audience

Free and open to the university community and the public


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CSO Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Jody Rosenblatt (U of Utah) http://molbio.princeton.edu/events/event/367-rosenblatt http://molbio.princeton.edu/events/event/367-rosenblatt Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Feb 25, 2015 - Wed, Feb 25, 2015
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Butler Seminar Series

Speaker
Jody
Judy Rosenblatt, Ph.D.
Associate Professor of Oncological Sciences, University of Utah
Huntsman Cancer Institute Investigator

Jody Rosenblatt is Associate Professor of Oncological Sciences at the University of Utah and Investigator at the Huntsman Cancer Institute.  Dr. Rosenblatt received her B.A. from the University of California, Berkeley and her Ph.D. from the University of California, San Francisco working with Dr. Timothy Mitchison.  As a post-doctoral fellow at the MRC-LMCB at University College London, she discovered epithelial cell extrusion; a process that eliminates dying cells without forming any gaps. Her lab found that typically when epithelial cells die during normal turnover, they do so by first extruding live cells when cell numbers become too dense. Extrusion is critical for regulating epithelial cell numbers, as extrusion signaling is misregulated in some of the most aggressive carcinomas and barrier function diseases. Additionally, her lab is finding that in addition to mechanical crowding causing cell death via extrusion, cell stretch causes cells to rapidly divide. Remarkably, the stretch-activated channel, Piezo-1, controls both crowding-induced extrusion and stretch-induced division in order to maintain constant epithelial cell numbers.

Seminar Topic

Epithelial cell turnover-new roles for mechanical tension driving cell death and division

Epithelial cells must maintain constant numbers to function as a barrier for the organs and organisms they coat. When they become too crowded, some cells are triggered to extrude and later die through activation of the stretch-activated channel, Piezo-1. Yet, when epithelial cells become too sparse to maintain a barrier, how is cell division triggered? Here, we show that mechanical stretch rapidly triggers epithelial cells to enter mitosis via the same Piezo-1 channel. Loss or inactivation of Piezo-1 prevents mitosis in response to mechanical stretch or wound healing. Piezo-1 controls progression into G2, as monolayers lacking it do not proliferate or accumulate cytoplasmic cyclin B following stretch. Unlike wild type monolayers Piezo-1 knockdown monolayers continue to migrate after closing a wound, suggesting Piezo-1 could link both control of cell proliferation and migration. Mechanical stretch only activates proliferation once epithelial cells reach homeostatic densities. Piezo-1 shifts from the nucleus in subconfluent epithelia to the plasma membrane and endoplasmic reticulum, sites where it could relay calcium currents, in confluent monolayers, suggesting a mechanism for how it may control stretch-induced proliferation upon reaching homeostasis. Our work suggests a new role for Piezo-1 controlling epithelial cell number homeostasis by mechanical stretch if cells become too sparse. Because Piezo-1 senses both mechanical crowding and stretch, it may act as a rheostat to control epithelial cell numbers by driving extrusion and apoptosis upon compression and cell division upon stretch.
 

Research lab


http://healthcare.utah.edu/huntsmancancerinstitute/research/labs/rosenblatt/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Eve Marder (Brandeis U) http://molbio.princeton.edu/events/event/404-marder http://molbio.princeton.edu/events/event/404-marder Location: PNI, Room A32 -
Category: Neuroscience Seminar Series
Date: Thu, Feb 26, 2015 - Thu, Feb 26, 2015
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Neuroscience Seminar Series

Speaker
Eve Marder
Eve Marder, Ph.D.
Brandeis University

Seminar Topic

 
TBA
 

FAculty Lab


https://blogs.brandeis.edu/marderlab/

Audience

Free and open to the university community and the public


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Neuroscience Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Carl-Philipp Heisenberg (IST Austria) http://molbio.princeton.edu/events/event/368-rosenblatt http://molbio.princeton.edu/events/event/368-rosenblatt Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Mar 04, 2015 - Wed, Mar 04, 2015
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Butler Seminar Series

Speaker
RTEmagicC heisenberg.jpg
Carl-Philipp Heisenberg, Ph.D.
IST Austria

Carl Philipp Heisenberg is professor at IST Austria.  He received his Ph.D. from Max-Planck-Institute of Developmental Biology Tübingen. The Heisenberg Lab is studying various forms of cell interactions underlying the development of multicellular structures, such as tissues, organs and embryos, using zebrafish gastrulation as an assay system.

Seminar Topic

 
TBA
 

Research lab


http://ist.ac.at/research-groups-pages/heisenberg-group/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Michael Rape (UC, Berkeley) http://molbio.princeton.edu/events/event/369-rape http://molbio.princeton.edu/events/event/369-rape Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Mar 11, 2015 - Wed, Mar 11, 2015
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Butler Seminar Series

Speaker
 Rape
Michael Rape, Ph.D.
University of California, Berkeley

Michael Rape is Howard Hughes Investigator and Professor of Cell and Developmental Biology at the University of California, Berkeley.  Michael studied Biochemistry in Bayreuth, Germany and received his PhD at the MPI in Martinsried, Germany in the lab of Stefan Jentsch.

Seminar Topic

 
TBA
 

Research lab


http://mcb.berkeley.edu/labs/rape/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
John Maunsell (Harvard) http://molbio.princeton.edu/events/event/405-maunsell http://molbio.princeton.edu/events/event/405-maunsell Location: PNI, Room A32 -
Category: Neuroscience Seminar Series
Date: Thu, Mar 12, 2015 - Thu, Mar 12, 2015
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Neuroscience Seminar Series

Speaker
maunsell-john
John Maunsell, Ph.D.
Harvard University

Seminar Topic

 
TBA
 

FAculty Lab


http://maunsell.med.harvard.edu/

Audience

Free and open to the university community and the public


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Neuroscience Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Karlene Cimprich (Stanford) http://molbio.princeton.edu/events/event/370-cimprich http://molbio.princeton.edu/events/event/370-cimprich Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Mar 25, 2015 - Wed, Mar 25, 2015
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Butler Seminar Series

Speaker
Cimprich
Karlene Cimprich, Ph.D.
Stanford University

Karlene Cimprich is Professor of Chemical and Systems Biology at Stanford University School of Medicine.  Karlene received her B.S. in Chemistry at the University of Notre Dame and her Ph.D. in Chemistry at Harvard University. Her lab focuses on genome stability pathways and their roles in cancer and other human diseases; DNA damage response pathways and DNA replication; the interface between RNA processing and transcription with genome stability.

Seminar Topic

 
TBA
 

Research lab


http://cimprich.stanford.edu/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Jeannie Lee (Harvard) http://molbio.princeton.edu/events/event/371-lee http://molbio.princeton.edu/events/event/371-lee Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Apr 01, 2015 - Wed, Apr 01, 2015
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Butler Seminar Series

Speaker
Jeannie Lee
Jeannie Lee, M.D., Ph.D.
Harvard Medical School

Jeannie Lee is Professor of Genetics and Pathology at Harvard Medical School, HHMI Investigator, and Molecular Biologist at Massachusetts General Hospital.  Professor Lee specializes in the study of epigenetic regulation by long noncoding RNA. Using X-inactivation as a model, her lab has made several contributions towards understanding how RNA directs chromatin and gene expression changes. She received her A.B. in Biochemistry & Molecular Biology from Harvard University, where she worked on antisense regulation with Professor Nancy Kleckner. She obtained the M.D.-Ph.D. degrees from the University of Pennsylvania School of Medicine, where she studied X-linked diseases with Professor Robert Nussbaum. At the Whitehead Institute/MIT, her postdoctoral work with Professor Rudolf Jaenisch delineated the X-inactivation center. She was Chief Resident of Clinical Pathology at the M.G.H., received the Basil O'Connor Award and the Pew Scholar Award as a young investigator, and was recently named a Distinguished Graduate of the University of Pennsylvania School of Medicine. She is also the recipient of the 2010 Molecular Biology Award from the National Academy of Sciences, USA, and is a Fellow of the American Association for the Advancement of Science (AAAS). She currently serves on the Board of Directors for the Genetics Society of America.

Seminar Topic

 
TBA
 

Research lab


http://molbio.mgh.harvard.edu/leeweb/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Bence Ölveczky (Harvard) http://molbio.princeton.edu/events/event/379-olveczky http://molbio.princeton.edu/events/event/379-olveczky Location: PNI, Room A32 -
Category: Neuroscience Seminar Series
Date: Thu, Apr 02, 2015 - Thu, Apr 02, 2015
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Neuroscience Seminar Series

Speaker
Bence
Bence Ölveczky, Ph.D.
Harvard University

Seminar Topic

 
TBA
 

research Lab


http://www.oeb.harvard.edu/faculty/olveczky/

Audience

Free and open to the university community and the public


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Neuroscience Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Tom Rapoport (Harvard) http://molbio.princeton.edu/events/event/372-cimprich http://molbio.princeton.edu/events/event/372-cimprich Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Tue, Apr 07, 2015 - Tue, Apr 07, 2015
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Butler Seminar Series

Speaker
Tom
Tom Rapoport, Ph.D.
Harvard Medical School

In January, 1995 Tom Rapoport joined the faculty of Harvard Medical School, arriving from the Max-Delbrück-Institute for Molecular Medicine in Berlin. He graduated with honors and earned his Ph.D. from Humboldt University in 1972. Immediately following this, Dr. Rapoport became an investigator of the Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR, which later became the Max-Delbrück-Institute. Since 1985, he has served as Professor of Cell Biology and group leader. In July of 1997 Tom was appointed as a Howard Hughes Medical Institute Investigator.

Seminar Topic

 
TBA
 

Research lab


http://rapoport.hms.harvard.edu/index.php/public/page/home

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Anthony N. van den Pol (Yale) http://molbio.princeton.edu/events/event/389-anthony-n-van-den-pol-yale http://molbio.princeton.edu/events/event/389-anthony-n-van-den-pol-yale Location: PNI, Room A32 -
Category: Behavioral Economics Seminars
Date: Thu, Apr 16, 2015 - Thu, Apr 16, 2015
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Behavioral Economics Seminars Thu, 25 Sep 2014 10:51:46 -0400