Matthew B. Neiditch (Rutgers University)
MolBio Seminar Series
Matthew B. Neiditch
Dr. Matthew Neiditch is an Associate Professor in the Department of Microbiology and Molecular Genetics at Rutgers - New Jersey Medical School. Dr. Neiditch received his B.S. at Rutgers where his earliest research employed analytical techniques to study chemical properties of non-nutritive sweeteners. He received his Ph.D. at Baylor College of Medicine where he studied the molecular mechanism of VDJ recombination in the laboratory of Dr. David Roth in the Department of Microbiology and Immunology and the Howard Hughes Medical Institute. Dr. Neiditch was a postdoctoral fellow in the laboratory of Dr. Frederick Hughson in the Department of Molecular Biology at Princeton University. Here, Dr. Neiditch carried out studies of bacterial cell-cell communication, which continues to be a primary area of research in his lab.
Dr. Neiditch’s group uses diverse methods including biochemical, genetic, computational, and biophysical (mainly X-ray crystallographic) techniques to study fundamentally important and broadly conserved cellular processes in bacteria. The basic science research in his lab encompasses structure-function studies of peptide-mediated bacterial cell-cell communication, c-di-GMP second messenger signal transduction, phosphorelay signal transduction, phosphatases, and transcriptional anti-activators, among others. The translational work in the Neiditch lab focuses on developing broad-spectrum inhibitors of bacterial biofilm growth and cell-cell communication as well as inhibitors of Mycobacterium tuberculosis mycolic acid biosynthesis.
Structural Biology of Cell-Cell Communication in Gram-Positive Bacteria
Pheromone-mediated cell-cell communication enables bacterial communities to coordinate social behaviors including, among others: virulence factor expression, motility, biofilm development, bioluminescence, antibiotic production, sporulation, and genetic competence. Typically, acylated homoserine lactones are used as pheromones by Gram-negative bacteria, whereas peptides are used by Gram-positive bacteria. This seminar will focus on the diverse cellular functions of the Gram-positive peptide pheromone receptors and their regulation by peptide pheromones. The results of genetic, biochemical, computational modeling, and X-ray crystallographic studies will be presented. The function and regulation of the pheromone receptors will be described in atomic detail, and the effects of pheromone receptor activity on bacterial communities will be discussed.
Free and open to the university community and the public