Yigong Shi (Tsinghua University)
Butler Seminar Series
Yigong Shi is a University Professor and Dean of the School of Life Sciences at Tsinghua University. He received his Bachelor’s Degree from Tsinghua University in 1989 and Ph.D. in Biophysics at Johns Hopkins University in 1995. Following post-doctoral training at the Memorial Sloan-Kettering Cancer Center, he joined Princeton University as an Assistant Professor in 1998 and was promoted to Full Professor in 2003. Yigong returned to Tsinghua University in 2008.
Yigong Shi is best known for his research into programmed cell death. He is a leader in the structural biology of cell signaling and macromolecular assemblies. Yigong received a number of recognitions, including the 2003 Irving Sigal Young Investigator Award from the Protein Society, the 2010 Sackler Prize in Biophysics, and the 2014 Gregori Aminoff Prize from the Royal Swedish Academy of Sciences.
Yigong Shi is a Fellow of the American Association for the Advancement of Science, a Foreign Associate of the US National Academy of Sciences, an Honorary Foreign Member of the American Academy of Arts and Sciences, and a Foreign Associate of the European Molecular Biology Organization (EMBO).
Structural Biology of Programmed Cell Death: From Princeton to Beijing
Programmed cell death, also known as apoptosis, is central to the development and homeostasis of all multi-cellular organisms. Dysregulation of apoptosis leads to a variety of human pathologies, including cancer, autoimmune diseases, and neurodegenerative disorders. Since the concept of apoptosis was established in 1972, research efforts have led to the identification of hundreds of genes that govern the initiation, execution, and regulation of apoptosis primarily in three model organisms: Caenorhabditis elegans (worms), Drosophila melanogaster (fruit flies), and mammals. The central pathway of apoptosis is conserved among the three organisms and involves the activation of cell-killing proteases known as caspases. In this lecture, I describe systematic characterization of the molecular mechanisms of programmed cell death by an integrated approach of structural biochemistry and biophysics.
Free and open to the university community and the public