Princeton University Molecular Biology - Molecular Biology Events http://molbio.princeton.edu Sat, 28 Feb 2015 01:40:35 -0500 Joomla! - Open Source Content Management en-gb Carl-Philipp Heisenberg (IST Austria) http://molbio.princeton.edu/events/event/368-carl-philipp-heisenberg-ist-austria http://molbio.princeton.edu/events/event/368-carl-philipp-heisenberg-ist-austria Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Mar 04, 2015 - Wed, Mar 04, 2015
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Butler Seminar Series

Speaker
Carl
Carl-Philipp Heisenberg, Ph.D.
Institute of Science and Technology Austria, Klosterneuburg, Austria


Carl Philipp Heisenberg is professor at IST Austria.  He received his Ph.D. from Max-Planck-Institute of Developmental Biology Tübingen. The Heisenberg Lab is studying various forms of cell interactions underlying the development of multicellular structures, such as tissues, organs and embryos, using zebrafish gastrulation as an assay system.

Seminar Topic

 

Surface cell expansion drives radial cell intercalations in zebrafish gastrulation

Radial cell intercalations are commonly associated with tissue spreading in many developmental and disease-related processes. Yet, how radial cell intercalations are controlled and function in tissue spreading remains unknown. Here, we use a combination of experiments and theory to analyze radial cell intercalations during doming, the initial spreading of the blastoderm over the yolk cell at early zebrafish gastrulation. Strikingly, we found that radial cell intercalations do not drive doming, but rather determine the viscous relaxation behavior of the blastoderm in response to tissue surface tension (TST)-driven deformation. We further show that the expansion of surface epithelial cells reduces TST, which in turn triggers radial cell intercalations and doming. Thus, radial cell intercalations are required for translating changes in tissue-scale forces into tissue deformation.
 

Research lab


http://ist.ac.at/research-groups-pages/heisenberg-group/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Michael Rape (UC, Berkeley) http://molbio.princeton.edu/events/event/369-rape http://molbio.princeton.edu/events/event/369-rape Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Mar 11, 2015 - Wed, Mar 11, 2015
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Butler Seminar Series

Speaker
 Michael Rape photo
Michael Rape, Ph.D.
Investigator, HHMI
Dr. K. Peter Hirth Chair in Cancer Biology and Professor in Cell and Developmental Biology, UC Berkeley

Michael Rape performed his graduate work with Stefan Jentsch at the Max Planck Institute of Biochemistry in Martinsried, Germany, where is discovered the p97/CDC48 complex as the first ubiquitin-dependent segregase. His postdoctoral work was performed with Marc Kirschner at Harvard Medical School, where Michael studied regulation of cell cycle control by the anaphase-promoting complex. In late 2006, Michael started his own lab at UC Berkeley, where he is currently a Professor in Cell and Developmental Biology and the Dr. K. Peter Hirth Chair in Cancer Biology. Michael has also co-founded a biotech company, Nurix. Awards include the Pew Scholars Award, the Vilcek Prize for Creative Promise, a Blavatnik Science Scholar, and the Howard Hughes Medical Institute Investigator Award.

Seminar Topic

 
Building a face, one ubiquitin at a time

Although ubiquitylation is known to control many aspects of cellular homeostasis, its function during cell differentiation programs remains incompletely understood. By combining high-throughput siRNA screens with expression analyses in stem cells, we have discovered a novel ubiquitylation enzyme that controls differentiation of human embryonic stem cells into neural crest. Loss of this ubiquitin ligase or its substrate results in craniofacial disorders caused by reduced numbers of neural crest cells. Importantly, by dissecting the molecular mechanism of this ubiquitin-dependent differentiation event, we revealed intriguing insight into cellular pathways that ultimately control cell fate decisions.
 

Research lab


http://mcb.berkeley.edu/labs/rape/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Karlene Cimprich (Stanford) http://molbio.princeton.edu/events/event/370-cimprich http://molbio.princeton.edu/events/event/370-cimprich Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Mar 25, 2015 - Wed, Mar 25, 2015
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Butler Seminar Series

Speaker
Cimprich
Karlene Cimprich, Ph.D.
Stanford University

Karlene Cimprich is Professor of Chemical and Systems Biology at Stanford University School of Medicine.  Karlene received her B.S. in Chemistry at the University of Notre Dame and her Ph.D. in Chemistry at Harvard University. Her lab focuses on genome stability pathways and their roles in cancer and other human diseases; DNA damage response pathways and DNA replication; the interface between RNA processing and transcription with genome stability.

Seminar Topic

 
TBA
 

Research lab


http://cimprich.stanford.edu/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Jeannie Lee (Harvard) http://molbio.princeton.edu/events/event/371-lee http://molbio.princeton.edu/events/event/371-lee Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Apr 01, 2015 - Wed, Apr 01, 2015
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Butler Seminar Series

Speaker
Jeannie Lee
Jeannie Lee, M.D., Ph.D.
Harvard Medical School

Jeannie Lee is Professor of Genetics and Pathology at Harvard Medical School, HHMI Investigator, and Molecular Biologist at Massachusetts General Hospital.  Professor Lee specializes in the study of epigenetic regulation by long noncoding RNA. Using X-inactivation as a model, her lab has made several contributions towards understanding how RNA directs chromatin and gene expression changes. She received her A.B. in Biochemistry & Molecular Biology from Harvard University, where she worked on antisense regulation with Professor Nancy Kleckner. She obtained the M.D.-Ph.D. degrees from the University of Pennsylvania School of Medicine, where she studied X-linked diseases with Professor Robert Nussbaum. At the Whitehead Institute/MIT, her postdoctoral work with Professor Rudolf Jaenisch delineated the X-inactivation center. She was Chief Resident of Clinical Pathology at the M.G.H., received the Basil O'Connor Award and the Pew Scholar Award as a young investigator, and was recently named a Distinguished Graduate of the University of Pennsylvania School of Medicine. She is also the recipient of the 2010 Molecular Biology Award from the National Academy of Sciences, USA, and is a Fellow of the American Association for the Advancement of Science (AAAS). She currently serves on the Board of Directors for the Genetics Society of America.

Seminar Topic

 
TBA
 

Research lab


http://molbio.mgh.harvard.edu/leeweb/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Tom Rapoport (Harvard) http://molbio.princeton.edu/events/event/372-cimprich http://molbio.princeton.edu/events/event/372-cimprich Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Tue, Apr 07, 2015 - Tue, Apr 07, 2015
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Butler Seminar Series

Speaker
Tom
Tom Rapoport, Ph.D.
Harvard Medical School

In January, 1995 Tom Rapoport joined the faculty of Harvard Medical School, arriving from the Max-Delbrück-Institute for Molecular Medicine in Berlin. He graduated with honors and earned his Ph.D. from Humboldt University in 1972. Immediately following this, Dr. Rapoport became an investigator of the Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR, which later became the Max-Delbrück-Institute. Since 1985, he has served as Professor of Cell Biology and group leader. In July of 1997 Tom was appointed as a Howard Hughes Medical Institute Investigator.

Seminar Topic

 
TBA
 

Research lab


http://rapoport.hms.harvard.edu/index.php/public/page/home

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400