Edwin Munro (Univ. of Chicago)

Dynamical basis for self-organizing cortical polarity in early C. elegans embryos
Date
May 17, 2017, 12:00 pm12:00 pm
Location
Thomas Laboratory, 003
Audience
Free and open to the university community and the public.

Speakers

Edwin Munro, Ph.D.
Principal Investigator
University of Chicago

Details

Event Description

Abstract: We are using the C. elegans zygote as a model to understand basic principles that govern self-organizing cortical polarity.  Zygotic polarity is specified by the asymmetric enrichment of highly conserved polarity determinants, known as PAR proteins, into complementary anterior and posterior cortical domains. PAR asymmetries are established in response to a transient sperm-derived cue and then dynamically maintained, after the cue is gone, through local PAR protein interactions and local coupling to the cortical actomyosin cytoskeleton. Our goal is to understand how robust, self-stabilizing, cortical polarity emerges through these local interactions.  In this talk, I will summarize our current understanding of how this works, focusing on three main organizing principles: (1) Mutual antagonism, in which anterior and posterior PAR proteins compete with one another to inhibit cortical binding and/or activity; (2) local clustering of polarity proteins, which leads to ultrasensitive dependence of cortical binding on the densities of proteins and their local antagonists, and which couples polarity proteins to the actomyosin cortex; and (3) mechanochemical feedback coupling in which PAR proteins modulate actomyosin contractility and cortical flows to promote (or inhibit) their own redistribution.

Sponsor
Danelle Devenport, Department of Molecular Biology
Event Category
Butler Seminar Series