Carl Nathan (Weill Cornell Medical College)

Carl Nathan (Weill Cornell Medical College)

Butler Seminar Series

Event Date/Location

April 5, 2017 - 12:00 pm
Thomas Laboratory 003


  • Picture of Dr. Carl Nathan

    Carl Nathan

    Professor and chairman of the Department of Microbiology and Immunology
    Weill Cornell Medical College, Cornell University


Overcoming Phenotypic Tolerance in Mycobacterium tuberculosis

Antimicrobial resistance (AMR) is one of the world’s top health challenges. Mycobacterium tuberculosis (Mtb), the single leading cause of death from infectious disease, may cause the greatest number of infections characterized by AMR and is becoming progressively incurable. The most familiar form of AMR is heritable, but non-heritable AMR—phenotypic tolerance—is one of the major factors that make tuberculosis difficult to treat. My lab is taking three routes to search for compounds active against Mtb in states in which it is phenotypically tolerant to most TB drugs: whole cell screening under non-replicating conditions; target-based screening against enzymes that Mtb needs to survive under stresses that block its replication; and testing active agents from those screens against Mtb in a state where it can no longer form colonies on solid media, yet retains the potential to cause disease.


Free and open to the university community and the public.


Mark Brynildsen, Department of Molecular Biology