Princeton University Molecular Biology - Archived Events http://molbio.princeton.edu Thu, 02 Jul 2015 23:19:33 -0400 Joomla! - Open Source Content Management en-gb Commencement 2015 http://molbio.princeton.edu/events/archive/event/434-commencement http://molbio.princeton.edu/events/archive/event/434-commencement Location: Nassau Hall -
Category: Undergraduate Important Dates & Deadlines
Date: Tue, Jun 02, 2015 - Tue, Jun 02, 2015
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Princeton University's 268th Commencement

Commencement. 11:00 a.m. (guests must be seated by 10:20 a.m.). Granting of degrees and address by President Eisgruber. Distribution of diplomas in the Residential Colleges for seniors follows.

Visit the University commencement page for more information.  

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Undergraduate Important Dates & Deadlines Tue, 31 Mar 2015 20:38:07 -0400
Class Day http://molbio.princeton.edu/events/archive/event/433-class-day http://molbio.princeton.edu/events/archive/event/433-class-day Location: Carl Icahn Atrium - Princeton
Category: Undergraduate Important Dates & Deadlines
Date: Mon, Jun 01, 2015 - Mon, Jun 01, 2015
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Class Day Ceremony begins at 3:30PM

Reception immediately following ceremony

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Undergraduate Important Dates & Deadlines Tue, 31 Mar 2015 20:38:07 -0400
Mohamed Abou Donia (Princeton) http://molbio.princeton.edu/events/archive/event/447-mohamed-abou-donia-princeton http://molbio.princeton.edu/events/archive/event/447-mohamed-abou-donia-princeton Location: Schultz Lab, 107 - Princeton
Category: Reunion Science Seminar
Date: Fri, May 29, 2015 - Fri, May 29, 2015
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Reunions Science Seminar

Speaker
 Mohamed
Mohamed Abou Donia
Molecular Biology, Princeton

Mohamed Abou Donia is assistant professor of Molecular Biology at Princeton University.  Dr. Donia received his B.Sc in Pharmacy from the Faculty of Pharmacy, Suez Canal University, Egypt in 2004. He moved to the US in 2005 to study for his Ph.D. at the Medicinal Chemistry Department, School of Pharmacy, University of Utah. He worked in Dr. Eric Schmidt's laboratory where he studied the chemistry and biology of small molecules produced by bacterial symbionts of marine animals. He used chemical, microbiological, and metagenomic techniques to study the role of small molecules in mediating microbe-host and microbe-microbe interactions in marine invertebrates. In 2010, he joined Dr. Michael Fischbach's laboratory at the Department of Bioengineering and Therapeutic Sciences at the University of California, San Francisco. There, he studied small molecules produced by members of the human microbiome and their role in mediating microbe-host and microbe-microbe interactions in humans. In particular, he focused on antibiotics produced by human pathogens and commensals, and their role in shaping the composition and dynamics of the human vaginal and oral microbiota.

Seminar Topic

Bacteria Living In and On the Human Body: An Unexpected First Line of Defense

website

http://molbio.princeton.edu/faculty/molbio-faculty/794-donia

Audience

Free and open to the university community and the public

Followed immediately by the Joint MolBio/EEB Picnic at Eno Glade

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Reunion Science Seminar Wed, 13 May 2015 12:12:01 -0400
Senior oral exams http://molbio.princeton.edu/events/archive/event/436-senior-oral-exams http://molbio.princeton.edu/events/archive/event/436-senior-oral-exams Location: No Location Available (TBD) -
Category: Undergraduate Important Dates & Deadlines
Date: Tue, May 12, 2015 - Fri, May 15, 2015
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May 12-15, 2015

Summer oral exams (dates subject to change).

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Undergraduate Important Dates & Deadlines Tue, 31 Mar 2015 20:38:07 -0400
Spring Junior paper due http://molbio.princeton.edu/events/archive/event/437-spring-junior-paper-due http://molbio.princeton.edu/events/archive/event/437-spring-junior-paper-due Location: No Location Available (TBD) -
Category: Undergraduate Important Dates & Deadlines: Research
Date: Tue, May 05, 2015 - Tue, May 05, 2015
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Junior paper due 

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Undergraduate Important Dates & Deadlines: Research Tue, 31 Mar 2015 20:38:07 -0400
Markus Ralser (U Cambridge) http://molbio.princeton.edu/events/archive/event/423-ralser http://molbio.princeton.edu/events/archive/event/423-ralser Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Apr 27, 2015 - Mon, Apr 27, 2015
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Quantitative & Computional Biology Fri, 06 Feb 2015 16:24:33 -0500
Senior thesis due http://molbio.princeton.edu/events/archive/event/438-senior-thesis-due http://molbio.princeton.edu/events/archive/event/438-senior-thesis-due Location: No Location Available (TBD) -
Category: Undergraduate Important Dates & Deadlines: Research
Date: Fri, Apr 24, 2015 - Fri, Apr 24, 2015
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April 24, 2015

The Dept. of Molecular Biology will be accepting senior thesis submissions from 9:00AM-5:00PM in

the main office (Rm 119) of Lewis Thomas Lab.

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Undergraduate Important Dates & Deadlines: Research Tue, 31 Mar 2015 20:38:07 -0400
Adam Kepecs (Cold Spring Harbor Laboratory) http://molbio.princeton.edu/events/archive/event/442-kepecs http://molbio.princeton.edu/events/archive/event/442-kepecs Location: PNI, Room A32 -
Category: Neuroscience Seminar Series
Date: Thu, Apr 23, 2015 - Thu, Apr 23, 2015
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Neuroscience Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Senior thesis readers assigned http://molbio.princeton.edu/events/archive/event/440-senior-thesis-readers-assigned http://molbio.princeton.edu/events/archive/event/440-senior-thesis-readers-assigned Location: No Location Available (TBD) -
Category: Undergraduate Important Dates & Deadlines: Major,Undergraduate Important Dates & Deadlines: Research
Date: Thu, Apr 23, 2015 - Thu, Apr 23, 2015
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April 23, 2015

Senior thesis reader assigned.

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Undergraduate Important Dates & Deadlines: Major,Undergraduate Important Dates & Deadlines: Research Tue, 31 Mar 2015 20:38:07 -0400
Kevin Thornton (EEB, UC, Irvine) http://molbio.princeton.edu/events/archive/event/422-kevin-thornton-eeb-uc-irvine http://molbio.princeton.edu/events/archive/event/422-kevin-thornton-eeb-uc-irvine Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Apr 20, 2015 - Mon, Apr 20, 2015
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Quantitative & Computional Biology Fri, 06 Feb 2015 16:24:33 -0500
Anthony N. van den Pol (Yale) http://molbio.princeton.edu/events/archive/event/389-anthony-n-van-den-pol-yale http://molbio.princeton.edu/events/archive/event/389-anthony-n-van-den-pol-yale Location: PNI, Room A32 -
Category: Behavioral Economics Seminars
Date: Thu, Apr 16, 2015 - Thu, Apr 16, 2015
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Behavioral Economics Seminars Thu, 25 Sep 2014 10:51:46 -0400
Robert Vonderheide (UPenn) http://molbio.princeton.edu/events/archive/event/430-vonderheide http://molbio.princeton.edu/events/archive/event/430-vonderheide Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Apr 15, 2015 - Wed, Apr 15, 2015
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Butler Seminar Series

Speaker
Vonderheide photo
Robert H. Vonderheide, MD, DPhil
Abramson Cancer Center
University of Pennsylvania

Robert H. Vonderheide, MD, D. Phil, is Professor of Medicine and the Hanna Wise Professor in Cancer Research at the Perelman School of Medicine at the University of Pennsylvania and an investigator of the Abramson Family Cancer Research Institute. He is a member of the Abramson Cancer Center where he serves as the Associate Director for Translational Research. He is Vice Chief of Research for Hematology-Oncology. Dr. Vonderheide graduated from the University of Notre Dame with a bachelor of science degree in Chemical Engineering and from Oxford University, England, as a Rhodes Scholar with a doctor of philosophy (D.Phil) degree in Immunology. After graduating from Harvard Medical School, Dr. Vonderheide completed a residency in Internal Medicine at the Massachusetts General Hospital and subsequently a clinical fellowship in hematology-oncology at the Dana-Farber Cancer Institute, where he trained with Dr. Lee Nadler. He is board certified in medical oncology. Dr. Vonderheide combines efforts in both basic research and clinical investigation to advance the understanding of tumor immunology and to develop novel immunotherapies for cancer, with a focus on pancreatic cancer. Dr. Vonderheide is a member of the Scientific Advisory Board for the Pancreatic Cancer Action Network. He serves as Deputy Editor for Cancer Immunology Research (a new journal from the American Association of Cancer Research), and he is an elected member of the American Society of Clinical Investigation and the American Association of Physicians.

Seminar Topic

Inflammatory networks and immune surveillance of cancer

Cancer-associated inflammation plays an important role in restraining anti-tumor immunity, particularly in pancreatic ductal adenocarcinoma (PDA) for which a massive infiltration of immunosuppressive leukocytes into the tumor stroma is an early and consistent event in oncogenesis. Intratumoral effector T cells are rare. This pathophysiology is in contrast to many other solid tumors for which infiltration of effector T cells is often prominent, associated with improved clinical outcomes, and mechanistically contributes to tumor immunoediting that ultimately can mediate immune escape. In PDA, increasing evidence suggests that the ras oncogene drives an inflammatory program that establishes immune privilege in the tumor microenvironment. Indeed, PDA cells might remain intrinsically sensitive to T cell killing because they have never been exposed to T cell selective pressure in vivo. In support of this hypothesis, recent studies demonstrate that derailing immune suppressive pathways in the PDA microenvironment, such as tumor derived GM-CSF, facilitates T-cell mediated tumor rejection. This viewpoint carries major implications for the development of novel, combination immunotherapies for pancreatic cancer.

Research lab

http://www.med.upenn.edu/apps/faculty/index.php/g20000220/p1073

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Ryan Baugh (Duke) http://molbio.princeton.edu/events/archive/event/421-ryan-baugh-duke http://molbio.princeton.edu/events/archive/event/421-ryan-baugh-duke Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Apr 13, 2015 - Mon, Apr 13, 2015
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Developmental responses to feast and famine: gene regulation, signaling networks and epigenetic effects

Life in the wild is often feast or famine. Developmental responses to nutrient stress are therefore critical to organismal fitness and highly relevant to disease. We study nutritional control of development in the roundworm C. elegans, focusing on starvation-induced developmental arrest in the first larval stage. I will discuss transcriptional mechanisms that provide reciprocal control of growth and stress gene expression in response to nutrient availability. I will also discuss an organismal signaling network that coordinates development and arrest across the animal. I will conclude by discussing how developmental arrest fits into the lifecycle of the animal, describing maternal and epigenetic effects of nutrient stress on various life history traits as well as some of the genes that mediate and modify these effects.

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Quantitative & Computional Biology Fri, 06 Feb 2015 16:24:33 -0500
Senior Thesis Reader Choices and Thesis Title Due http://molbio.princeton.edu/events/archive/event/439-Senior%20Thesis%20Reader%20Choices%20and%20Thesis%20Title%20Due http://molbio.princeton.edu/events/archive/event/439-Senior%20Thesis%20Reader%20Choices%20and%20Thesis%20Title%20Due Location: No Location Available (TBD) -
Category: Undergraduate Important Dates & Deadlines: Major,Undergraduate Important Dates & Deadlines: Research
Date: Thu, Apr 09, 2015 - Thu, Apr 09, 2015
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April 9, 2015

Senior Thesis Reader Choice and Thesis Title Due

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Undergraduate Important Dates & Deadlines: Major,Undergraduate Important Dates & Deadlines: Research Tue, 31 Mar 2015 20:38:07 -0400
Sophomore Open House http://molbio.princeton.edu/events/archive/event/425-sophomore-open-house http://molbio.princeton.edu/events/archive/event/425-sophomore-open-house Location: Schultz Lab, 107 - Princeton
Category: Undergraduate Important Dates & Deadlines
Date: Wed, Apr 08, 2015 - Wed, Apr 08, 2015
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The Sophomore Open House is designed to help sophomores learn about departmental programs and requirements and to give sophomores a better sense of what it is like to be an undergraduate concentrator.  This year, sophomores will be required to declare their departmental concentration online between April 13-21 and will select their fall courses between April 22-24. 

 
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Undergraduate Important Dates & Deadlines Tue, 10 Mar 2015 15:59:23 -0400
Tom Rapoport (Harvard) http://molbio.princeton.edu/events/archive/event/431-tom-rapoport-harvard http://molbio.princeton.edu/events/archive/event/431-tom-rapoport-harvard Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Apr 08, 2015 - Wed, Apr 08, 2015
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Butler Seminar Series

Carter-Wallace Seminar 

Speaker
rapoport photo
Tom Rapoport, Ph.D.
Professor of Cell Biology and HHMI Investigator
Harvard Medical School


In January, 1995 Tom Rapoport joined the faculty of Harvard Medical School, arriving from the Max-Delbrück-Institute for Molecular Medicine in Berlin. He graduated with honors and earned his Ph.D. from Humboldt University in 1972. Immediately following this, Dr. Rapoport became an investigator of the Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR, which later became the Max-Delbrück-Institute. Since 1985, he has served as Professor of Cell Biology and group leader. In July of 1997 Tom was appointed as a Howard Hughes Medical Institute Investigator.  Rapoport is a member of the National Academies of the USA and Germany.  He has received several awards. 

Seminar Topic

Mechanism of ERAD elucidated with purified components

Abstract: Misfolded proteins of the endoplasmic reticulum (ER) are retro-translocated into the cytosol, poly-ubiquitinated, and degraded by the proteasome, a process called ER-associated protein degradation (ERAD). We have used purified components from Saccharomyces cerevisiae to analyze the mechanism of retro-translocation of luminal and membrane substrates (ERAD-L and -M), recapitulating key steps in a basic process where the ubiquitin ligase Hrd1p is the only required membrane protein. We show that Hrd1p interacts with substrate through its membrane-spanning domain, discriminating misfolded from folded polypeptides. In the following step, Hrd1p is auto-ubiquitinated, causing a conformational change in Hrd1p, which allows substrate to move across the membrane and be poly-ubiquitinated as well. Next, the Cdc48p ATPase complex is recruited and uses ATP hydrolysis to release poly-ubiquitinated proteins from the membrane. Finally, ubiquitin chains are trimmed by the de-ubiquitinating enzyme Otu1p, resulting in the release of substrate from the Cdc48p complex. Our results suggest a model for retro-translocation in which multi-spanning ubiquitin ligases form membrane conduits for misfolded proteins.

Research lab


http://rapoport.hms.harvard.edu/index.php/public/page/home

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Tom Rapoport (Harvard) http://molbio.princeton.edu/events/archive/event/372-tom-rapoport-harvard http://molbio.princeton.edu/events/archive/event/372-tom-rapoport-harvard Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Tue, Apr 07, 2015 - Tue, Apr 07, 2015
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Butler Seminar Series

Carter-Wallace Seminar 

Tuesday, April 7, 2015, 4pm | Wednesday, April 8, 12pm

Speaker
rapoport photo
Tom Rapoport, Ph.D.
Professor of Cell Biology and HHMI Investigator
Harvard Medical School


In January, 1995 Tom Rapoport joined the faculty of Harvard Medical School, arriving from the Max-Delbrück-Institute for Molecular Medicine in Berlin. He graduated with honors and earned his Ph.D. from Humboldt University in 1972. Immediately following this, Dr. Rapoport became an investigator of the Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR, which later became the Max-Delbrück-Institute. Since 1985, he has served as Professor of Cell Biology and group leader. In July of 1997 Tom was appointed as a Howard Hughes Medical Institute Investigator.  Rapoport is a member of the National Academies of the USA and Germany.  He has received several awards. 

Seminar Topic

How an organelle gets into shape

Abstract: How is the characteristic shape of a membrane-bound organelle achieved? We have addressed the mechanism for the endoplasmic reticulum (ER), an organelle at which many proteins are synthesized, including secretory and plasma membrane proteins. The ER consists of different domains, the nuclear envelope and the peripheral ER that contains a tubular network with interdispersed sheets. How these domains are generated has been mysterious. We have discovered proteins that shape the tubules and others that allow them to fuse to form a network. We also found mechanisms by which the sheets are generated and discovered that sheets are stacked on top of each other in a manner that resembles a parking garage.

Research lab


http://rapoport.hms.harvard.edu/index.php/public/page/home

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Guy Sella (Columbia) http://molbio.princeton.edu/events/archive/event/420-guy-sella-columbia http://molbio.princeton.edu/events/archive/event/420-guy-sella-columbia Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Apr 06, 2015 - Mon, Apr 06, 2015
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Quantitative & Computational Biology Seminar

Speaker
Guy Sella 
Guy Sella
Columbia University
 
Seminar Topic

A population genetic perspective on disease susceptibility and other quantitative traits

Many phenotypes of interest, including susceptibility to many common diseases, are “quantitative”, in that the heritable variation in the trait is largely due to numerous genetic variants of small effects segregating in the population. The causes of quantitative genetic variation have been studied in evolutionary biology for over a century. This pursuit has recently come to the forefront of research in human genetics as well, with the push to map variants that underlie heritable genetic variation in phenotypes. Notably, since 2007, genome-wide association studies (GWAS) in humans have led to the identification of thousands of variants reproducibly associated with hundreds of quantitative traits, including susceptibility to a wide variety of diseases. These studies reveal intriguing differences among traits in their genetic architecture (i.e., the number of associated variants, their effect sizes and frequencies) and in the fraction of the heritable variation explained. Interpreting these findings has been difficult, however, in no small part because we lack generative models relating population genetic processes (e.g., pleiotropy, selection and genetic drift) with the genetic architecture of quantitative traits. I will present such a model and how it helps to understand the results of GWAS. I will also discuss how the results of GWAS can be used to infer the forces underlying quantitative genetic variation and how an improved understanding of genetic architecture may help in understanding the basis of adaptation in humans and other taxa.

website

http://www.columbia.edu/cu/biology/faculty-data/guy-sella/faculty.html

Audience

Free and open to the university community and the public


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Quantitative & Computional Biology Fri, 06 Feb 2015 16:24:33 -0500
Bence Ölveczky (Harvard) http://molbio.princeton.edu/events/archive/event/379-olveczky http://molbio.princeton.edu/events/archive/event/379-olveczky Location: PNI, Room A32 -
Category: Neuroscience Seminar Series
Date: Thu, Apr 02, 2015 - Thu, Apr 02, 2015
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Neuroscience Seminar Series

Speaker
Bence
Bence Ölveczky, Ph.D.
Harvard University

Seminar Topic

 
TBA
 

research Lab


http://www.oeb.harvard.edu/faculty/olveczky/

Audience

Free and open to the university community and the public


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Neuroscience Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Jeannie Lee (Harvard) http://molbio.princeton.edu/events/archive/event/371-lee http://molbio.princeton.edu/events/archive/event/371-lee Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Apr 01, 2015 - Wed, Apr 01, 2015
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Butler Seminar Series

Speaker
Jeannie Lee
Jeannie Lee, M.D., Ph.D.
Harvard Medical School

Jeannie Lee is Professor of Genetics and Pathology at Harvard Medical School, HHMI Investigator, and Molecular Biologist at Massachusetts General Hospital.  Professor Lee specializes in the study of epigenetic regulation by long noncoding RNA. Using X-inactivation as a model, her lab has made several contributions towards understanding how RNA directs chromatin and gene expression changes. She received her A.B. in Biochemistry & Molecular Biology from Harvard University, where she worked on antisense regulation with Professor Nancy Kleckner. She obtained the M.D.-Ph.D. degrees from the University of Pennsylvania School of Medicine, where she studied X-linked diseases with Professor Robert Nussbaum. At the Whitehead Institute/MIT, her postdoctoral work with Professor Rudolf Jaenisch delineated the X-inactivation center. She was Chief Resident of Clinical Pathology at the M.G.H., received the Basil O'Connor Award and the Pew Scholar Award as a young investigator, and was recently named a Distinguished Graduate of the University of Pennsylvania School of Medicine. She is also the recipient of the 2010 Molecular Biology Award from the National Academy of Sciences, USA, and is a Fellow of the American Association for the Advancement of Science (AAAS). She currently serves on the Board of Directors for the Genetics Society of America.

Seminar Topic

 
TBA
 

Research lab


http://molbio.mgh.harvard.edu/leeweb/

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400